Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1094481..1094968 Replicon chromosome
Accession NZ_LR134484
Organism Gemella haemolysans strain NCTC10459

Toxin (Protein)


Gene name relE Uniprot ID C5NYE0
Locus tag EL214_RS04865 Protein ID WP_003145533.1
Coordinates 1094481..1094744 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C5NYD9
Locus tag EL214_RS04870 Protein ID WP_003144945.1
Coordinates 1094744..1094968 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL214_RS04845 1090819..1091463 - 645 WP_003145587.1 hypothetical protein -
EL214_RS04850 1091656..1092705 + 1050 WP_003144914.1 PTS sugar transporter subunit IIC -
EL214_RS04855 1092877..1093698 + 822 WP_003145294.1 lipoate--protein ligase family protein -
EL214_RS04860 1093778..1094437 - 660 WP_003145163.1 hypothetical protein -
EL214_RS04865 1094481..1094744 - 264 WP_003145533.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL214_RS04870 1094744..1094968 - 225 WP_003144945.1 hypothetical protein Antitoxin
EL214_RS04875 1095178..1097760 - 2583 WP_003145411.1 ATP-dependent chaperone ClpB -
EL214_RS04880 1098145..1099839 + 1695 WP_003145427.1 AIPR family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10464.27 Da        Isoelectric Point: 10.4227

>T287930 WP_003145533.1 NZ_LR134484:c1094744-1094481 [Gemella haemolysans]
MYKIVFDEAIKKDLKKLDKQTLKILFSWIEKNLSNTDDPRGMGKALVGNKKGYWRYRIGDYRLITRIEDDRLIIIAINFK
HRREVYS

Download         Length: 264 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8644.78 Da        Isoelectric Point: 4.1532

>AT287930 WP_003144945.1 NZ_LR134484:c1094968-1094744 [Gemella haemolysans]
MTTLTLRLNKEEEQIFNSISGLYGGKLSTTIKQLALEKIEDEYDLQLIKDFESREEKGEVTLIEFDDLKKEFDL

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C5NYE0

Antitoxin

Source ID Structure
AlphaFold DB C5NYD9

References