Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpA-brnA/BrnT_toxin-BrnA
Location 2382950..2383481 Replicon chromosome
Accession NZ_LR134480
Organism Bordetella bronchiseptica strain NCTC8344

Toxin (Protein)


Gene name shpA Uniprot ID K0MH61
Locus tag EL399_RS11250 Protein ID WP_003812626.1
Coordinates 2382950..2383216 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID K0MF02
Locus tag EL399_RS11255 Protein ID WP_003816743.1
Coordinates 2383203..2383481 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL399_RS11225 2378077..2378349 + 273 WP_003812615.1 hypothetical protein -
EL399_RS11230 2378388..2379098 - 711 WP_003812617.1 aquaporin Z -
EL399_RS11235 2379209..2379841 - 633 WP_003812619.1 PAS domain-containing protein -
EL399_RS11240 2380238..2381116 + 879 WP_033450228.1 tripartite tricarboxylate transporter substrate binding protein -
EL399_RS11245 2381178..2382719 + 1542 WP_010928296.1 M81 family metallopeptidase -
EL399_RS11250 2382950..2383216 + 267 WP_003812626.1 BrnT family toxin Toxin
EL399_RS11255 2383203..2383481 + 279 WP_003816743.1 BrnA antitoxin family protein Antitoxin
EL399_RS11265 2383803..2384459 - 657 WP_033456960.1 phosphoribosylanthranilate isomerase -
EL399_RS11270 2384474..2386141 - 1668 WP_003812634.1 TRAP transporter large permease subunit -
EL399_RS11275 2386144..2386773 - 630 WP_003812635.1 TRAP transporter small permease subunit -
EL399_RS11280 2386985..2388079 - 1095 WP_003812637.1 TRAP transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(12-86)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10037.47 Da        Isoelectric Point: 7.9923

>T287926 WP_003812626.1 NZ_LR134480:2382950-2383216 [Bordetella bronchiseptica]
MDITYDPAKNDKNIADRGLSFELVCGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Download         Length: 267 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10412.89 Da        Isoelectric Point: 10.5548

>AT287926 WP_003816743.1 NZ_LR134480:2383203-2383481 [Bordetella bronchiseptica]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0MH61

Antitoxin

Source ID Structure
AlphaFold DB K0MF02

References