Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2085908..2086569 Replicon chromosome
Accession NZ_LR134480
Organism Bordetella bronchiseptica strain NCTC8344

Toxin (Protein)


Gene name vapC Uniprot ID Q7WAH5
Locus tag EL399_RS09885 Protein ID WP_003812073.1
Coordinates 2086144..2086569 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EL399_RS09880 Protein ID WP_003812071.1
Coordinates 2085908..2086147 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL399_RS09845 2080943..2081746 - 804 WP_003812055.1 bacteriocin family protein -
EL399_RS09850 2081743..2082789 - 1047 WP_003812057.1 Dyp-type peroxidase -
EL399_RS09855 2082867..2083427 - 561 WP_010926528.1 DUF488 domain-containing protein -
EL399_RS09860 2083424..2083657 - 234 WP_033447224.1 DUF2945 domain-containing protein -
EL399_RS09865 2083738..2084250 - 513 WP_033474080.1 redoxin domain-containing protein -
EL399_RS09870 2084309..2084854 - 546 WP_033452198.1 peroxidase-related enzyme -
EL399_RS09875 2084992..2085834 + 843 WP_033474079.1 AraC family transcriptional regulator -
EL399_RS09880 2085908..2086147 + 240 WP_003812071.1 Arc family DNA-binding protein Antitoxin
EL399_RS09885 2086144..2086569 + 426 WP_003812073.1 PIN domain-containing protein Toxin
EL399_RS09890 2086679..2087143 + 465 WP_003812075.1 MarR family transcriptional regulator -
EL399_RS09895 2087249..2088754 - 1506 WP_003812078.1 tripartite tricarboxylate transporter permease -
EL399_RS09900 2089253..2089765 + 513 WP_110124032.1 hypothetical protein -
EL399_RS09905 2089786..2090763 - 978 WP_003812083.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14811.22 Da        Isoelectric Point: 6.3704

>T287925 WP_003812073.1 NZ_LR134480:2086144-2086569 [Bordetella bronchiseptica]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Download         Length: 426 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8561.78 Da        Isoelectric Point: 11.5658

>AT287925 WP_003812071.1 NZ_LR134480:2085908-2086147 [Bordetella bronchiseptica]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7WAH5

Antitoxin

Source ID Structure

References