Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3090594..3091219 Replicon chromosome
Accession NZ_LR134478
Organism Serratia plymuthica strain NCTC8015

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EL316_RS14925 Protein ID WP_006321377.1
Coordinates 3090594..3090776 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL316_RS14930 Protein ID WP_126528271.1
Coordinates 3090806..3091219 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL316_RS14920 3086456..3090427 + 3972 WP_126528270.1 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase -
EL316_RS14925 3090594..3090776 + 183 WP_006321377.1 type II toxin-antitoxin system HicA family toxin Toxin
EL316_RS14930 3090806..3091219 + 414 WP_126528271.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL316_RS14935 3091252..3092004 - 753 WP_062871168.1 L-cystine ABC transporter ATP-binding protein YecC -
EL316_RS14940 3092008..3092670 - 663 WP_006321381.1 cystine ABC transporter permease -
EL316_RS14945 3092670..3093470 - 801 WP_126483416.1 cystine ABC transporter substrate-binding protein -
EL316_RS14950 3093585..3094577 - 993 WP_126528272.1 D-cysteine desulfhydrase -
EL316_RS14955 3094703..3095212 - 510 WP_126483420.1 flagella biosynthesis regulatory protein FliZ -
EL316_RS14960 3095269..3095991 - 723 WP_126483422.1 RNA polymerase sigma factor FliA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7004.29 Da        Isoelectric Point: 11.5336

>T287911 WP_006321377.1 NZ_LR134478:3090594-3090776 [Serratia plymuthica]
VKSAELIRLLEREGWVLERIKGSHHQFKHPRSRLVITVPHPRKDLKPGTLRQIMRDAGLC

Download         Length: 183 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15046.78 Da        Isoelectric Point: 4.8469

>AT287911 WP_126528271.1 NZ_LR134478:3090806-3091219 [Serratia plymuthica]
MFYPAYVHSDHDGSASGFFPDVPGCYFAGDTLDIAFEDAKSALDAHFELLSEDNQVIPRPQAVSFHLAQASDTLNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELLKAG

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References