Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1577526..1578079 Replicon chromosome
Accession NZ_LR134478
Organism Serratia plymuthica strain NCTC8015

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag EL316_RS07675 Protein ID WP_119803676.1
Coordinates 1577771..1578079 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag EL316_RS07670 Protein ID WP_006322175.1
Coordinates 1577526..1577768 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL316_RS07655 1574014..1575552 + 1539 WP_126527741.1 glutathione ABC transporter substrate-binding protein GsiB -
EL316_RS07660 1575605..1576525 + 921 WP_126527742.1 glutathione ABC transporter permease GsiC -
EL316_RS07665 1576535..1577443 + 909 WP_172603336.1 glutathione ABC transporter permease GsiD -
EL316_RS07670 1577526..1577768 + 243 WP_006322175.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
EL316_RS07675 1577771..1578079 + 309 WP_119803676.1 CcdB family protein Toxin
EL316_RS07680 1578116..1578958 - 843 WP_126481398.1 S-formylglutathione hydrolase -
EL316_RS07685 1578973..1580100 - 1128 WP_164713374.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
EL316_RS07690 1580129..1581046 - 918 WP_126481400.1 LysR family transcriptional regulator -
EL316_RS07695 1581154..1582311 + 1158 WP_126481402.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(10-80)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11533.40 Da        Isoelectric Point: 5.0758

>T287904 WP_119803676.1 NZ_LR134478:1577771-1578079 [Serratia plymuthica]
MQFTVYDNIYPASAYPYLLDVQSDLIDVLSTRLMIPLYSLEKVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGEA
VGNANEHRNKIKAAIDFLIDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9183.30 Da        Isoelectric Point: 4.7719

>AT287904 WP_006322175.1 NZ_LR134478:1577526-1577768 [Serratia plymuthica]
MDMANSNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRAF

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References