Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1127181..1127803 Replicon chromosome
Accession NZ_LR134478
Organism Serratia plymuthica strain NCTC8015

Toxin (Protein)


Gene name Hha Uniprot ID S4YCZ4
Locus tag EL316_RS05390 Protein ID WP_006322256.1
Coordinates 1127181..1127384 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S4YKH5
Locus tag EL316_RS05395 Protein ID WP_004949348.1
Coordinates 1127435..1127803 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL316_RS05380 1122987..1124357 + 1371 WP_126480739.1 amidase -
EL316_RS05385 1124405..1126345 - 1941 WP_126527600.1 NAD(P)/FAD-dependent oxidoreductase -
EL316_RS05390 1127181..1127384 - 204 WP_006322256.1 hemolysin expression modulator Hha Toxin
EL316_RS05395 1127435..1127803 - 369 WP_004949348.1 Hha toxicity modulator TomB Antitoxin
EL316_RS05400 1127964..1128290 - 327 WP_126480745.1 hypothetical protein -
EL316_RS05410 1128769..1129482 + 714 WP_126480749.1 ABC transporter ATP-binding protein -
EL316_RS05415 1129479..1130336 + 858 WP_073439483.1 metal ABC transporter permease -
EL316_RS05420 1130362..1131240 + 879 WP_126527601.1 metal ABC transporter substrate-binding protein -
EL316_RS05425 1131356..1131496 - 141 WP_013811779.1 type B 50S ribosomal protein L36 -
EL316_RS05430 1131509..1131763 - 255 WP_126480753.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8085.45 Da        Isoelectric Point: 6.9764

>T287903 WP_006322256.1 NZ_LR134478:c1127384-1127181 [Serratia plymuthica]
MTKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14203.92 Da        Isoelectric Point: 4.5140

>AT287903 WP_004949348.1 NZ_LR134478:c1127803-1127435 [Serratia plymuthica]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KM53

Antitoxin

Source ID Structure
AlphaFold DB S4YKH5

References