Detailed information of TA system TA287901

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 548033..549371
• Replicon: chromosome
• Accession: NZ_LR134478
• Organism: Serratia plymuthica strain NCTC8015

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: EL316_RS02585
• Protein ID: WP_126527432.1
• Coordinates: 548421..549371 (+)
• Length: 317 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: EL316_RS02580
• Protein ID: WP_119804576.1
• Coordinates: 548033..548428 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL316_RS02560	543929..544999	+	1071	WP_126479976.1	LPS export ABC transporter permease LptG	-
EL316_RS02565	545203..545919	+	717	WP_126527430.1	LuxR family transcriptional regulator	-
EL316_RS02570	545920..546564	-	645	WP_126527431.1	acyl-homoserine-lactone synthase	-
EL316_RS02580	548033..548428	+	396	WP_119804576.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
EL316_RS02585	548421..549371	+	951	WP_126527432.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
EL316_RS02590	549780..550415	+	636	WP_126527433.1	carbonic anhydrase	-
EL316_RS02595	550568..550864	+	297	WP_126527434.1	helix-turn-helix transcriptional regulator	-
EL316_RS02600	551240..551773	+	534	WP_126528983.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	545203..573707	28504

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (37-301)

Antitoxin

• Protein of unknown function DUF6088 (7-125)

Sequences

Toxin

Protein

• Length: 317 a.a.
• Molecular weight: 35913.25 Da
• Isoelectric Point: 4.6340

>T287901 WP_126527432.1 NZ_LR134478:548421-549371 [Serratia plymuthica]
MDDLTTLFPDVADALGIESVAIVEKDYYIVELLRLLQPLVFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPAAGFSQ
QYSRGQRKNIRKGIIQTIIETIAASGTFRLDEEYPKVTRDEYRYNEIPVRYPQEYAQIPCLRPFIKLELMETDLLEVAEN
RAISSLVMDLTKKGEVVGAFPCATITSTQAEKLISMMRRTAASMRDVERAVDESLVRHIYDNFCIVREKGSDVPVLKHLV
QECIEQDIERYGAQYPEFCESPVEELKMGLEELASNPVYKERYLHFVTPMVFGKSQVSWEEAYICFRKTALDVVDA

Nucleotide

• Length: 951 bp

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14405.69 Da
• Isoelectric Point: 10.9938

>AT287901 WP_119804576.1 NZ_LR134478:548033-548428 [Serratia plymuthica]
MTIKARIQSRLKRSKRYVFTRDDFKDLAGYDQIGRALRELVKEGQLLKVGYGVYTKARQNVITGKLMPAAPGGSAAVVIE
ALERLNVDYRLVGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGNSKLNG

Nucleotide

• Length: 396 bp