Detailed information of TA system TA028790

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 554388..555208
• Replicon: chromosome
• Accession: NC_020163
• Organism: Escherichia coli APEC O78

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: APECO78_RS02730
• Protein ID: WP_001054379.1
• Coordinates: 554951..555208 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: APECO78_RS02725
• Protein ID: WP_000123957.1
• Coordinates: 554388..554939 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
APECO78_RS02700	550082..551395	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
APECO78_RS02705	551407..551685	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
APECO78_RS02710	551682..552803	-	1122	WP_000010833.1	M42 family metallopeptidase	-
APECO78_RS27080	553048..553164	-	117	Protein_495	VOC family protein	-
APECO78_RS02715	553202..553462	-	261	WP_000077646.1	hypothetical protein	-
APECO78_RS02720	553590..554336	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
APECO78_RS02725	554388..554939	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
APECO78_RS02730	554951..555208	-	258	WP_001054379.1	YjhX family toxin	Toxin
APECO78_RS02735	555585..555884	-	300	WP_001332034.1	GNAT family N-acetyltransferase	-
APECO78_RS02740	555962..557188	+	1227	Protein_501	helicase YjhR	-
APECO78_RS02745	557771..558751	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
APECO78_RS02750	558815..559921	-	1107	WP_001295733.1	N-acetylneuraminate epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T28790 WP_001054379.1 NC_020163:c555208-554951 [Escherichia coli APEC O78]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T28790 NC_020163:c555208-554951 [Escherichia coli APEC O78]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT28790 WP_000123957.1 NC_020163:c554939-554388 [Escherichia coli APEC O78]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT28790 NC_020163:c554939-554388 [Escherichia coli APEC O78]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030