Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3958640..3959259 Replicon chromosome
Accession NZ_LR134475
Organism Klebsiella aerogenes strain NCTC9735

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag EL280_RS19345 Protein ID WP_015367918.1
Coordinates 3959041..3959259 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag EL280_RS19340 Protein ID WP_015367917.1
Coordinates 3958640..3959014 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL280_RS19330 3953798..3954997 + 1200 WP_020079451.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EL280_RS19335 3955020..3958166 + 3147 WP_015367916.1 multidrug efflux RND transporter permease subunit -
EL280_RS19340 3958640..3959014 + 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
EL280_RS19345 3959041..3959259 + 219 WP_015367918.1 hemolysin expression modulator Hha Toxin
EL280_RS19350 3959391..3959954 + 564 WP_020079452.1 maltose O-acetyltransferase -
EL280_RS19360 3960080..3960544 + 465 WP_015367920.1 YlaC family protein -
EL280_RS19365 3960519..3961973 - 1455 WP_126338664.1 PLP-dependent aminotransferase family protein -
EL280_RS19370 3962076..3962786 + 711 WP_126338313.1 GNAT family N-acetyltransferase -
EL280_RS19375 3962783..3962923 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
EL280_RS19380 3962926..3963186 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T287897 WP_015367918.1 NZ_LR134475:3959041-3959259 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT287897 WP_015367917.1 NZ_LR134475:3958640-3959014 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References