Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2652818..2653557 Replicon chromosome
Accession NZ_LR134475
Organism Klebsiella aerogenes strain NCTC9735

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag EL280_RS12885 Protein ID WP_126337963.1
Coordinates 2653072..2653557 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H3FSM9
Locus tag EL280_RS12880 Protein ID WP_015705366.1
Coordinates 2652818..2653084 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL280_RS12855 2648153..2648740 + 588 WP_126337959.1 hypothetical protein -
EL280_RS12860 2648737..2650056 + 1320 WP_126337961.1 sensor histidine kinase -
EL280_RS12865 2650056..2650673 + 618 WP_020078884.1 response regulator transcription factor -
EL280_RS12870 2650769..2651266 + 498 WP_015705368.1 heme-binding protein -
EL280_RS12875 2651310..2652545 - 1236 WP_020078885.1 MFS transporter -
EL280_RS12880 2652818..2653084 + 267 WP_015705366.1 DUF1778 domain-containing protein Antitoxin
EL280_RS12885 2653072..2653557 + 486 WP_126337963.1 GNAT family N-acetyltransferase Toxin
EL280_RS12890 2653629..2655245 + 1617 WP_126337965.1 FAD-NAD(P)-binding protein -
EL280_RS12895 2655364..2656464 + 1101 WP_015366663.1 NADH:flavin oxidoreductase/NADH oxidase -
EL280_RS12900 2656521..2656679 - 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
EL280_RS12905 2656940..2658010 + 1071 WP_047465487.1 mannonate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(25-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17649.30 Da        Isoelectric Point: 8.5242

>T287896 WP_126337963.1 NZ_LR134475:2653072-2653557 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGMKNQAQGAARTFVVCKEDSHQVVGFYSLATGSVNHTEATGDLRRNM
PDPIPVIILARLAIDCAFHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.56 Da        Isoelectric Point: 4.6558

>AT287896 WP_015705366.1 NZ_LR134475:2652818-2653084 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FSM9

References