Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 835923..836580 Replicon chromosome
Accession NZ_LR134475
Organism Klebsiella aerogenes strain NCTC9735

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag EL280_RS04155 Protein ID WP_015369792.1
Coordinates 836170..836580 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag EL280_RS04150 Protein ID WP_015369791.1
Coordinates 835923..836189 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL280_RS04125 831150..832583 - 1434 WP_032712496.1 6-phospho-beta-glucosidase BglA -
EL280_RS04130 832703..833431 - 729 WP_045391997.1 MurR/RpiR family transcriptional regulator -
EL280_RS04135 833482..833793 + 312 WP_046881935.1 N(4)-acetylcytidine aminohydrolase -
EL280_RS04140 833958..834617 + 660 WP_047065377.1 hemolysin III family protein -
EL280_RS04145 834716..835699 - 984 WP_015369790.1 tRNA-modifying protein YgfZ -
EL280_RS04150 835923..836189 + 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
EL280_RS04155 836170..836580 + 411 WP_015369792.1 protein YgfX Toxin
EL280_RS04160 836588..837109 - 522 WP_015369793.1 flavodoxin FldB -
EL280_RS04165 837210..838106 + 897 WP_015703420.1 site-specific tyrosine recombinase XerD -
EL280_RS04170 838129..838842 + 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EL280_RS04175 838848..840581 + 1734 WP_063421698.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T287891 WP_015369792.1 NZ_LR134475:836170-836580 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT287891 WP_015369791.1 NZ_LR134475:835923-836189 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References