Detailed information of TA system TA287886

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PHD(antitoxin)
• Location: 2811101..2811756
• Replicon: chromosome
• Accession: NZ_LR134442
• Organism: Propionibacterium australiense strain NCTC13651

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: EL282_RS12465
• Protein ID: WP_119161305.1
• Coordinates: 2811361..2811756 (+)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: EL282_RS12460
• Protein ID: WP_119161306.1
• Coordinates: 2811101..2811364 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL282_RS12440	2807807..2808496	+	690	WP_197720593.1	TetR/AcrR family transcriptional regulator	-
EL282_RS12445	2808493..2809341	+	849	WP_119161307.1	ABC transporter ATP-binding protein	-
EL282_RS12450	2809431..2810453	+	1023	WP_197720594.1	hypothetical protein	-
EL282_RS12455	2810378..2810896	+	519	WP_197720595.1	hypothetical protein	-
EL282_RS12460	2811101..2811364	+	264	WP_119161306.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
EL282_RS12465	2811361..2811756	+	396	WP_119161305.1	type II toxin-antitoxin system VapC family toxin	Toxin
EL282_RS12470	2811794..2813041	-	1248	WP_119161304.1	MFS transporter	-
EL282_RS12475	2813499..2814224	-	726	WP_119161404.1	TetR family transcriptional regulator	-
EL282_RS12480	2814394..2815473	-	1080	WP_119161303.1	inositol-3-phosphate synthase	-
EL282_RS12485	2815525..2816553	-	1029	WP_119161302.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-120)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (5-43)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14254.31 Da
• Isoelectric Point: 4.5901

>T287886 WP_119161305.1 NZ_LR134442:2811361-2811756 [Propionibacterium australiense]
MTICYLDTSAALKLLIEEAESESLGSWLTGEVTDGMTLCSSFLLHVELHCAARRRHRLDEQAVASLLAGIELIDISREHL
LAAARDTTGLRAADAIHLAVALDVRSDLLLTYDQEMQNAAQQRALTVVAPV

Nucleotide

• Length: 396 bp

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9648.08 Da
• Isoelectric Point: 11.9478

>AT287886 WP_119161306.1 NZ_LR134442:2811101-2811364 [Propionibacterium australiense]
MTVTTIPHRELRNDSAAILRRVEAGESFIVTNNGRAVAELIPITRDRLALLRQQGATRPATPVDFSALRRIRGLRSKDVL
ADLRGES

Nucleotide

• Length: 264 bp