Detailed information of TA system TA287882

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-DinJ
• Location: 997229..997613
• Replicon: chromosome
• Accession: NZ_LR134442
• Organism: Propionibacterium australiense strain NCTC13651

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: EL282_RS13875
• Protein ID: WP_197720653.1
• Coordinates: 997461..997613 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: EL282_RS04325
• Protein ID: WP_119162819.1
• Coordinates: 997229..997474 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL282_RS04305	992866..994269	-	1404	WP_170175669.1	DHA2 family efflux MFS transporter permease subunit	-
EL282_RS04310	994304..994735	-	432	WP_170175670.1	MarR family transcriptional regulator	-
EL282_RS04315	995337..995789	+	453	WP_119162821.1	helix-turn-helix domain-containing protein	-
EL282_RS13615	995749..996057	+	309	Protein_855	hypothetical protein	-
EL282_RS04325	997229..997474	+	246	WP_119162819.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
EL282_RS13875	997461..997613	+	153	WP_197720653.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
EL282_RS13880	997665..997790	+	126	WP_197720654.1	type II toxin-antitoxin system PemK/MazF family toxin	-
EL282_RS04335	997959..999218	+	1260	WP_119162818.1	ATP-binding protein	-
EL282_RS04340	999371..1000633	+	1263	WP_119162817.1	ATP-binding protein	-
EL282_RS04345	1000912..1001934	+	1023	WP_119162816.1	aldo/keto reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-41)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-58)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5451.21 Da
• Isoelectric Point: 4.7418

>T287882 WP_197720653.1 NZ_LR134442:997461-997613 [Propionibacterium australiense]
MKRGEVWTLRDDAYASKARPVVVVQSEEFPGFGSVVLCLFTGFDSSGIPT

Nucleotide

• Length: 153 bp

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9166.23 Da
• Isoelectric Point: 4.8096

>AT287882 WP_119162819.1 NZ_LR134442:997229-997474 [Propionibacterium australiense]
MATRQIATRVDAEQAELFKETTRRLGTTPADALRMFVTAFNSHRGFPYDVRLSEDVEPFATEEDATRFATDLSLKAINEA
R

Nucleotide

• Length: 246 bp