Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2250970..2251556 Replicon chromosome
Accession NZ_LR134440
Organism Neisseria animaloris strain NCTC12228

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EL216_RS10605 Protein ID WP_085390354.1
Coordinates 2251302..2251556 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL216_RS10600 Protein ID WP_085390277.1
Coordinates 2250970..2251305 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL216_RS10575 2247110..2247856 + 747 WP_085390272.1 DNA repair protein RecO -
EL216_RS10580 2247912..2248643 + 732 WP_085390273.1 pyridoxine 5'-phosphate synthase -
EL216_RS10585 2248691..2249068 + 378 WP_085390274.1 holo-ACP synthase -
EL216_RS10590 2249162..2249434 + 273 WP_085390275.1 ACT domain-containing protein -
EL216_RS10595 2249447..2250808 + 1362 WP_085390276.1 PFL family protein -
EL216_RS10600 2250970..2251305 - 336 WP_085390277.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL216_RS10605 2251302..2251556 - 255 WP_085390354.1 type II toxin-antitoxin system HicA family toxin Toxin
EL216_RS10610 2251725..2252501 - 777 WP_085390278.1 ferredoxin--NADP reductase -
EL216_RS10615 2252599..2253471 - 873 WP_085390279.1 YicC family protein -
EL216_RS10620 2253572..2254300 + 729 WP_085390280.1 ribonuclease PH -
EL216_RS10625 2254407..2255073 + 667 Protein_2058 deoxyribose-phosphate aldolase -
EL216_RS10630 2255180..2256352 - 1173 WP_197720432.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9519.00 Da        Isoelectric Point: 10.3121

>T287878 WP_085390354.1 NZ_LR134440:c2251556-2251302 [Neisseria animaloris]
MKKKHQRTLASIFSRPVPGSIKWADIEALFIELDAEIQEREGSRIAVILFGQVKVFHRPHPSPDTDKSAVASVRKWLEEN
GVKP

Download         Length: 255 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12104.56 Da        Isoelectric Point: 5.5565

>AT287878 WP_085390277.1 NZ_LR134440:c2251305-2250970 [Neisseria animaloris]
MNNVMEINGHKAIIQYDPETELLRGEFIGLNGGADFYADNVADLHKEGAASLAVFLDVCKEKGIEPYKQYSGRFNVRVSP
ETHAAAAAAAASQNISLNEWVNRAIRQCAHA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References