Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 444813..445457 Replicon chromosome
Accession NZ_LR134440
Organism Neisseria animaloris strain NCTC12228

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL216_RS02120 Protein ID WP_085360419.1
Coordinates 445062..445457 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EL216_RS02115 Protein ID WP_085389826.1
Coordinates 444813..445058 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL216_RS02095 440357..441367 + 1011 WP_085389823.1 2Fe-2S iron-sulfur cluster binding domain-containing protein -
EL216_RS02100 441463..442620 - 1158 WP_085389824.1 alpha-hydroxy-acid oxidizing protein -
EL216_RS02105 443015..443458 + 444 WP_054600297.1 Fe-S cluster assembly transcriptional regulator IscR -
EL216_RS02110 443494..444708 + 1215 WP_085389825.1 IscS subfamily cysteine desulfurase -
EL216_RS02115 444813..445058 + 246 WP_085389826.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EL216_RS02120 445062..445457 + 396 WP_085360419.1 type II toxin-antitoxin system VapC family toxin Toxin
EL216_RS02125 445584..445967 + 384 WP_085360421.1 Fe-S cluster assembly scaffold IscU -
EL216_RS02130 446027..446263 + 237 WP_085389827.1 recombinase RecA -
EL216_RS02135 446405..446725 + 321 WP_054600303.1 iron-sulfur cluster assembly protein IscA -
EL216_RS02140 446834..447370 + 537 WP_085356722.1 inorganic diphosphatase -
EL216_RS02145 447615..447968 - 354 WP_085356721.1 helix-turn-helix transcriptional regulator -
EL216_RS02150 448164..448400 + 237 WP_085389828.1 DUF896 domain-containing protein -
EL216_RS02155 448603..449478 + 876 WP_085389829.1 pirin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(7-37)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14444.70 Da        Isoelectric Point: 7.5203

>T287877 WP_085360419.1 NZ_LR134440:445062-445457 [Neisseria animaloris]
MRYLLDTNIVSHILRRQPNVMAKLQSVPMSDLYISAVTHAELMYGLAKKPDAAKLHRAVHELLLRIGVLPFDEQASTHYG
KFKAQAEQSGKNLASLDMMIAAHASAVSAVLVSNDAAFQQIADLSVEDWTK

Download         Length: 396 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9220.09 Da        Isoelectric Point: 4.2683

>AT287877 WP_085389826.1 NZ_LR134440:444813-445058 [Neisseria animaloris]
MQTAKLFQNGRSQAVRLPAAFRFTGDEVYIRRDEATGDVILSQRPGDWQGFIAAASELDESDTIERNTSIQQRDPFADWQ
E

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References