Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 105878..106412 Replicon plasmid 9
Accession NZ_LR134418
Organism Legionella adelaidensis strain NCTC12735

Toxin (Protein)


Gene name relE Uniprot ID A0A0W0R328
Locus tag EL206_RS01640 Protein ID WP_058461223.1
Coordinates 106131..106412 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A0W0R313
Locus tag EL206_RS01635 Protein ID WP_058461224.1
Coordinates 105878..106144 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL206_RS01620 102550..102879 - 330 WP_058461226.1 ferredoxin family protein -
EL206_RS01625 103073..105259 + 2187 WP_058461225.1 PAS domain S-box protein -
EL206_RS01630 105313..105678 + 366 WP_058462328.1 response regulator -
EL206_RS01635 105878..106144 + 267 WP_058461224.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EL206_RS01640 106131..106412 + 282 WP_058461223.1 type II toxin-antitoxin system YafQ family toxin Toxin
EL206_RS01660 107161..107724 - 564 WP_058462327.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
EL206_RS01665 107763..108419 - 657 WP_058461222.1 HAD-IA family hydrolase -
EL206_RS01670 108412..109353 - 942 WP_058461221.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pilE / ankH/legA3/ankW / pilT / enhA / lpg2359 / lpg2370 / lirB 1..451287 451287


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11106.73 Da        Isoelectric Point: 9.7931

>T287872 WP_058461223.1 NZ_LR134418:106131-106412 [Legionella adelaidensis]
MRTIEYTTQFKRDYKREIKGKYKAVFSNLFIEIIDTLARDEPLAAKHRDHALSNNWQDHRDCHIKPDLVLIYRKPDRQTL
QLVRLGSHSELSL

Download         Length: 282 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9883.33 Da        Isoelectric Point: 5.6864

>AT287872 WP_058461224.1 NZ_LR134418:105878-106144 [Legionella adelaidensis]
MTTNAVVRARIDEHIKEEASAVLASMGLTVSDAFRMLLTRIAKEHALPFEPLIPNQQTINAMKEARRGQLKSFKTVQSLM
DDLNNEDD

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0R328

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0R313

References