Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3069198..3069857 Replicon chromosome
Accession NZ_LR134406
Organism Arachnia propionica strain NCTC12967

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL272_RS13690 Protein ID WP_197720344.1
Coordinates 3069198..3069533 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A448N254
Locus tag EL272_RS13695 Protein ID WP_073970044.1
Coordinates 3069609..3069857 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL272_RS13665 3064805..3065461 - 657 WP_014847806.1 response regulator transcription factor -
EL272_RS13670 3065455..3066642 - 1188 WP_014847807.1 sensor histidine kinase -
EL272_RS13675 3066772..3067494 + 723 WP_061787614.1 ATP-binding cassette domain-containing protein -
EL272_RS13680 3067491..3068273 + 783 WP_061787613.1 ABC transporter permease -
EL272_RS13685 3068420..3068932 - 513 WP_061787612.1 lincomycin resistance protein LmrB -
EL272_RS13690 3069198..3069533 - 336 WP_197720344.1 PIN domain-containing protein Toxin
EL272_RS13695 3069609..3069857 - 249 WP_073970044.1 ribbon-helix-helix domain-containing protein Antitoxin
EL272_RS13700 3070126..3070365 + 240 WP_061787610.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
EL272_RS13705 3070365..3070724 + 360 WP_061787609.1 type II toxin-antitoxin system VapC family toxin -
EL272_RS13710 3070963..3072918 + 1956 WP_197720267.1 type I restriction-modification system subunit M -
EL272_RS13715 3072915..3074144 + 1230 WP_073970031.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-103)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12270.12 Da        Isoelectric Point: 8.5406

>T287871 WP_197720344.1 NZ_LR134406:c3069533-3069198 [Arachnia propionica]
MTADEPFGVSELILSGFLRIVTNHRVYREPTSPQVALDFCQTVLSASSAVRIRPGRGHWRIFESLCRNLGARGNVVPDAY
LAAMAIEADATFITMDAGFARFPGLTWRRAL

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8872.98 Da        Isoelectric Point: 5.1599

>AT287871 WP_073970044.1 NZ_LR134406:c3069857-3069609 [Arachnia propionica]
MRTTVNLDDELLRRAKERAARQGRTLSEVVSDALRVSLAEQAGPRREVTLPTFGGSGLKPGVDLEDKDALAALLGEDDRA
AR

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A448N254

References