Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 237704..238748 Replicon chromosome
Accession NC_020163
Organism Escherichia coli APEC O78

Toxin (Protein)


Gene name panT Uniprot ID A0A829CP20
Locus tag APECO78_RS01130 Protein ID WP_000019186.1
Coordinates 238200..238748 (+) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag APECO78_RS01125 Protein ID WP_000287252.1
Coordinates 237704..238177 (+) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APECO78_RS01100 232710..233318 + 609 WP_000646078.1 transcriptional repressor LexA -
APECO78_RS01105 233391..234716 + 1326 WP_001301116.1 MATE family efflux transporter DinF -
APECO78_RS01110 234832..235041 + 210 WP_001030593.1 CsbD family protein -
APECO78_RS01115 235083..235598 - 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
APECO78_RS01120 235916..236932 + 1017 WP_000912595.1 DUF2713 family protein -
APECO78_RS24285 237295..237417 + 123 WP_001300034.1 hypothetical protein -
APECO78_RS01125 237704..238177 + 474 WP_000287252.1 SocA family protein Antitoxin
APECO78_RS01130 238200..238748 + 549 WP_000019186.1 hypothetical protein Toxin
APECO78_RS01135 238782..239051 - 270 WP_001093912.1 pyocin activator PrtN family protein -
APECO78_RS01140 239088..239840 - 753 WP_001701368.1 hypothetical protein -
APECO78_RS01145 240057..240881 - 825 WP_015364383.1 DUF2303 family protein -
APECO78_RS01150 240946..241308 - 363 WP_000135682.1 hypothetical protein -
APECO78_RS01155 241975..242649 - 675 WP_000859462.1 LexA family transcriptional repressor -
APECO78_RS01160 242740..242961 + 222 WP_000649475.1 helix-turn-helix domain-containing protein -
APECO78_RS01165 243065..243664 + 600 WP_001230372.1 Ail/Lom family outer membrane beta-barrel protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 232710..259822 27112


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20026.39 Da        Isoelectric Point: 4.4481

>T28787 WP_000019186.1 NC_020163:238200-238748 [Escherichia coli APEC O78]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKAPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

>T28787 NC_020163:238200-238748 [Escherichia coli APEC O78]
ATGTCTCATAATTCAGATATCTATAAACTGATCGGAGCGGCCGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTCTACTGACAGTCAAGAGCAGGCTTTTGAATCCGCATTTGAGCCGTCTAATCATGAACGCGATGATGATTCTTCTTCAG
AAAATAAGGCTATTCTGGAGGAAGAAGAGTTTGGTTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGAACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGGGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAGCTCCGGACAAAAATGGCATCATTCACGGTTTGGTTTATGTCGTGTTGGTGCTTATTCGTTGTCGCAATGTTTA
CATCGTTTCTTATTGCACATGAAGGAAAGGCTCCAGTTGAAGCGATCGTTGCATTACTAGGTACAAGTACAATTAGTATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATAGTGATAAAGAAAAATAA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT28787 WP_000287252.1 NC_020163:237704-238177 [Escherichia coli APEC O78]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp

>AT28787 NC_020163:237704-238177 [Escherichia coli APEC O78]
ATGTACAGTCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAATGAATGTGTCTCCGCGT
GGAAGTACGGTCCAGTTATTCCTGGAATGTACGATGCTTTCAAAGACTATGGGAATAAACCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATCGTTACTATGGATCCGCAAGCAGAGAGCATTATCGGGGCTGTTTATAAGTTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCGA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CP20

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References