Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3857982..3859558 Replicon chromosome
Accession NZ_LR134396
Organism Providencia rustigianii strain NCTC8113

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EL244_RS17830 Protein ID WP_126462677.1
Coordinates 3857982..3859301 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EL244_RS17835 Protein ID WP_039855850.1
Coordinates 3859301..3859558 (-) Length 86 a.a.

Genomic Context

EL244_RS17825EL244_RS17820EL244_RS17830EL244_RS17835EL244_RS17840EL244_RS17845EL244_RS17850EL244_RS17855EL244_RS17860
Location: 3857141..3857971 (831 bp)
Type: Others
Protein ID: WP_126462674.1
Location: 3853918..3856965 (3048 bp)
Type: Others
Protein ID: WP_126462671.1
Location: 3857982..3859301 (1320 bp)
Type: Toxin
Protein ID: WP_126462677.1
Location: 3859301..3859558 (258 bp)
Type: Antitoxin
Protein ID: WP_039855850.1
Location: 3859719..3861083 (1365 bp)
Type: Others
Protein ID: WP_126462681.1
Location: 3861195..3862847 (1653 bp)
Type: Others
Protein ID: WP_006816153.1
Location: 3862850..3863110 (261 bp)
Type: Others
Protein ID: WP_036959180.1
Location: 3863074..3863433 (360 bp)
Type: Others
Protein ID: WP_006816151.1
Location: 3863451..3863594 (144 bp)
Type: Others
Protein ID: WP_004906236.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EL244_RS178203853918..3856965-3048WP_126462671.1formate dehydrogenase-N subunit alpha-
EL244_RS178253857141..3857971+831WP_126462674.1formate dehydrogenase accessory sulfurtransferase FdhD-
EL244_RS178303857982..3859301-1320WP_126462677.1type II toxin-antitoxin system HipA family toxinToxin
EL244_RS178353859301..3859558-258WP_039855850.1helix-turn-helix domain-containing proteinAntitoxin
EL244_RS178403859719..3861083-1365WP_126462681.1tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE-
EL244_RS178453861195..3862847-1653WP_006816153.1membrane protein insertase YidC-
EL244_RS178503862850..3863110-261WP_036959180.1membrane protein insertion efficiency factor YidD-
EL244_RS178553863074..3863433-360WP_006816151.1ribonuclease P protein component-
EL244_RS178603863451..3863594-144WP_004906236.150S ribosomal protein L34-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 50279.64 Da        Isoelectric Point: 6.8248

>T287865 WP_126462677.1 NZ_LR134396:c3859301-3857982 [Providencia rustigianii]
MATLYVYMNGYLVGEFIRSSTGAHQFKYDSHWLETPGARPISLSMPLQHQEYKGDEVYNFFDNLLPDNIEIRNRVVSRHQ
VDSNQPFDLLSKIGQDSVGALQLVPAEQTVSNVKQIEYKRLSTKKLEKILTGYRANIPLGMIDEVDDFRISIAGAQEKTA
LLNLDGHWYLPLNATPTTHIIKLPIGKIESHSYSIDLSESVENEYLCLLIAKEFGLDVPHSFILNIGEIKALVVEHFDRK
YSSDDTWIMRLPQEDFCQTLNVSPARKYQSHGGPGIQEIMDYLLGSINVEKDRYQFMKSQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPSYGGREIHPRDAKLAMGLKGKKGIKYEIEQIFPRHFFATAKAVGFARAEMEKILIEFDEKM
DSVIKKVRKQLPLDFPEHIANSILSGLHHKAERLKKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9628.81 Da        Isoelectric Point: 8.5613

>AT287865 WP_039855850.1 NZ_LR134396:c3859558-3859301 [Providencia rustigianii]
MKVTNTRQLSAYMKDVRETNKLSQSKVASKVGIRQDTVSSFELSPDSTKLETFFKILSALNLELDIKPRNESGSSNTDSG
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References