Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3857982..3859558 Replicon chromosome
Accession NZ_LR134396
Organism Providencia rustigianii strain NCTC8113

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EL244_RS17830 Protein ID WP_126462677.1
Coordinates 3857982..3859301 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EL244_RS17835 Protein ID WP_039855850.1
Coordinates 3859301..3859558 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL244_RS17820 3853918..3856965 - 3048 WP_126462671.1 formate dehydrogenase-N subunit alpha -
EL244_RS17825 3857141..3857971 + 831 WP_126462674.1 formate dehydrogenase accessory sulfurtransferase FdhD -
EL244_RS17830 3857982..3859301 - 1320 WP_126462677.1 type II toxin-antitoxin system HipA family toxin Toxin
EL244_RS17835 3859301..3859558 - 258 WP_039855850.1 helix-turn-helix domain-containing protein Antitoxin
EL244_RS17840 3859719..3861083 - 1365 WP_126462681.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
EL244_RS17845 3861195..3862847 - 1653 WP_006816153.1 membrane protein insertase YidC -
EL244_RS17850 3862850..3863110 - 261 WP_036959180.1 membrane protein insertion efficiency factor YidD -
EL244_RS17855 3863074..3863433 - 360 WP_006816151.1 ribonuclease P protein component -
EL244_RS17860 3863451..3863594 - 144 WP_004906236.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 50279.64 Da        Isoelectric Point: 6.8248

>T287865 WP_126462677.1 NZ_LR134396:c3859301-3857982 [Providencia rustigianii]
MATLYVYMNGYLVGEFIRSSTGAHQFKYDSHWLETPGARPISLSMPLQHQEYKGDEVYNFFDNLLPDNIEIRNRVVSRHQ
VDSNQPFDLLSKIGQDSVGALQLVPAEQTVSNVKQIEYKRLSTKKLEKILTGYRANIPLGMIDEVDDFRISIAGAQEKTA
LLNLDGHWYLPLNATPTTHIIKLPIGKIESHSYSIDLSESVENEYLCLLIAKEFGLDVPHSFILNIGEIKALVVEHFDRK
YSSDDTWIMRLPQEDFCQTLNVSPARKYQSHGGPGIQEIMDYLLGSINVEKDRYQFMKSQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPSYGGREIHPRDAKLAMGLKGKKGIKYEIEQIFPRHFFATAKAVGFARAEMEKILIEFDEKM
DSVIKKVRKQLPLDFPEHIANSILSGLHHKAERLKKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9628.81 Da        Isoelectric Point: 8.5613

>AT287865 WP_039855850.1 NZ_LR134396:c3859558-3859301 [Providencia rustigianii]
MKVTNTRQLSAYMKDVRETNKLSQSKVASKVGIRQDTVSSFELSPDSTKLETFFKILSALNLELDIKPRNESGSSNTDSG
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References