Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 3791087..3791673 Replicon chromosome
Accession NZ_LR134396
Organism Providencia rustigianii strain NCTC8113

Toxin (Protein)


Gene name PumA Uniprot ID D1P7T6
Locus tag EL244_RS17510 Protein ID WP_006816297.1
Coordinates 3791371..3791673 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EL244_RS17505 Protein ID WP_006816296.1
Coordinates 3791087..3791374 (-) Length 96 a.a.

Genomic Context

EL244_RS17480EL244_RS17520EL244_RS17525EL244_RS17485EL244_RS17490EL244_RS17495EL244_RS17500EL244_RS17505EL244_RS17510EL244_RS17515
Location: 3787267..3787479 (213 bp)
Type: Others
Protein ID: WP_006816290.1
Location: 3792615..3793313 (699 bp)
Type: Others
Protein ID: WP_006816216.1
Location: 3793310..3794680 (1371 bp)
Type: Others
Protein ID: WP_006816215.1
Location: 3787609..3788553 (945 bp)
Type: Others
Protein ID: WP_006816291.1
Location: 3788550..3789191 (642 bp)
Type: Others
Protein ID: WP_039855930.1
Location: 3789403..3790158 (756 bp)
Type: Others
Protein ID: WP_006816294.1
Location: 3790381..3790962 (582 bp)
Type: Others
Protein ID: WP_126462566.1
Location: 3791087..3791374 (288 bp)
Type: Antitoxin
Protein ID: WP_006816296.1
Location: 3791371..3791673 (303 bp)
Type: Toxin
Protein ID: WP_006816297.1
Location: 3791897..3792463 (567 bp)
Type: Others
Protein ID: WP_006816217.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EL244_RS174803787267..3787479+213WP_006816290.1RNA chaperone/antiterminator CspA-
EL244_RS174853787609..3788553-945WP_006816291.1phosphatidate cytidylyltransferase-
EL244_RS174903788550..3789191-642WP_039855930.11-acyl-sn-glycerol-3-phosphate acyltransferase-
EL244_RS174953789403..3790158-756WP_006816294.1M48 family metallopeptidase-
EL244_RS175003790381..3790962-582WP_126462566.1HutD family protein-
EL244_RS175053791087..3791374-288WP_006816296.1putative addiction module antidote proteinAntitoxin
EL244_RS175103791371..3791673-303WP_006816297.1type II toxin-antitoxin system RelE/ParE family toxinToxin
EL244_RS175153791897..3792463-567WP_006816217.1Spy/CpxP family protein refolding chaperone-
EL244_RS175203792615..3793313+699WP_006816216.1envelope stress response regulator transcription factor CpxR-
EL244_RS175253793310..3794680+1371WP_006816215.1envelope stress sensor histidine kinase CpxA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11597.41 Da        Isoelectric Point: 10.0958

>T287864 WP_006816297.1 NZ_LR134396:c3791673-3791371 [Providencia rustigianii]
MLTVFTTDIFDKWMHELKDIRAKTKIQVRIRRLKNGNFGDVESIGEGFSELKIHEGKGYRVYLKKVENTIVLLINGGSKS
TQQKDIDRAKQIFREIEGDL

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10595.29 Da        Isoelectric Point: 5.7011

>AT287864 WP_006816296.1 NZ_LR134396:c3791374-3791087 [Providencia rustigianii]
MSIKIKEYDIAEHLASEEEIQLYLNEILEEGDPALILSALGDIARARNMTQLAKDVGMSREGLYKALSGQGNPTFTTIMK
IVHSLGFKLQFKRAL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBD1P7T6

Antitoxin

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Source
ID
Structure
No matching records found

References