Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 3791087..3791673 Replicon chromosome
Accession NZ_LR134396
Organism Providencia rustigianii strain NCTC8113

Toxin (Protein)


Gene name PumA Uniprot ID D1P7T6
Locus tag EL244_RS17510 Protein ID WP_006816297.1
Coordinates 3791371..3791673 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EL244_RS17505 Protein ID WP_006816296.1
Coordinates 3791087..3791374 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL244_RS17480 3787267..3787479 + 213 WP_006816290.1 RNA chaperone/antiterminator CspA -
EL244_RS17485 3787609..3788553 - 945 WP_006816291.1 phosphatidate cytidylyltransferase -
EL244_RS17490 3788550..3789191 - 642 WP_039855930.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
EL244_RS17495 3789403..3790158 - 756 WP_006816294.1 M48 family metallopeptidase -
EL244_RS17500 3790381..3790962 - 582 WP_126462566.1 HutD family protein -
EL244_RS17505 3791087..3791374 - 288 WP_006816296.1 putative addiction module antidote protein Antitoxin
EL244_RS17510 3791371..3791673 - 303 WP_006816297.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL244_RS17515 3791897..3792463 - 567 WP_006816217.1 Spy/CpxP family protein refolding chaperone -
EL244_RS17520 3792615..3793313 + 699 WP_006816216.1 envelope stress response regulator transcription factor CpxR -
EL244_RS17525 3793310..3794680 + 1371 WP_006816215.1 envelope stress sensor histidine kinase CpxA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11597.41 Da        Isoelectric Point: 10.0958

>T287864 WP_006816297.1 NZ_LR134396:c3791673-3791371 [Providencia rustigianii]
MLTVFTTDIFDKWMHELKDIRAKTKIQVRIRRLKNGNFGDVESIGEGFSELKIHEGKGYRVYLKKVENTIVLLINGGSKS
TQQKDIDRAKQIFREIEGDL

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10595.29 Da        Isoelectric Point: 5.7011

>AT287864 WP_006816296.1 NZ_LR134396:c3791374-3791087 [Providencia rustigianii]
MSIKIKEYDIAEHLASEEEIQLYLNEILEEGDPALILSALGDIARARNMTQLAKDVGMSREGLYKALSGQGNPTFTTIMK
IVHSLGFKLQFKRAL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D1P7T6

Antitoxin

Source ID Structure

References