Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2508745..2509400 Replicon chromosome
Accession NZ_LR134396
Organism Providencia rustigianii strain NCTC8113

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EL244_RS11580 Protein ID WP_071599550.1
Coordinates 2508745..2508930 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID D1P354
Locus tag EL244_RS11585 Protein ID WP_006814675.1
Coordinates 2508987..2509400 (+) Length 138 a.a.

Genomic Context

EL244_RS11580EL244_RS11585EL244_RS11605EL244_RS11610EL244_RS11560EL244_RS11565EL244_RS11570EL244_RS11575EL244_RS11590EL244_RS11595EL244_RS11600
Location: 2508745..2508930 (186 bp)
Type: Toxin
Protein ID: WP_071599550.1
Location: 2508987..2509400 (414 bp)
Type: Antitoxin
Protein ID: WP_006814675.1
Location: 2511802..2512719 (918 bp)
Type: Others
Protein ID: WP_006814679.1
Location: 2512877..2514010 (1134 bp)
Type: Others
Protein ID: WP_126461052.1
Location: 2504658..2505746 (1089 bp)
Type: Others
Protein ID: WP_126461046.1
Location: 2505749..2506609 (861 bp)
Type: Others
Protein ID: WP_126461049.1
Location: 2506609..2507439 (831 bp)
Type: Others
Protein ID: WP_006814673.1
Location: 2507439..2508461 (1023 bp)
Type: Others
Protein ID: WP_115164490.1
Location: 2509458..2510354 (897 bp)
Type: Others
Protein ID: WP_006814676.1
Location: 2510569..2511153 (585 bp)
Type: Others
Protein ID: WP_039855044.1
Location: 2511235..2511666 (432 bp)
Type: Others
Protein ID: WP_006814678.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EL244_RS115602504658..2505746-1089WP_126461046.1sulfate/thiosulfate ABC transporter ATP-binding protein CysA-
EL244_RS115652505749..2506609-861WP_126461049.1sulfate/thiosulfate ABC transporter permease CysW-
EL244_RS115702506609..2507439-831WP_006814673.1sulfate/thiosulfate ABC transporter permease CysT-
EL244_RS115752507439..2508461-1023WP_115164490.1sulfate ABC transporter substrate-binding protein-
EL244_RS115802508745..2508930+186WP_071599550.1type II toxin-antitoxin system HicA family toxinToxin
EL244_RS115852508987..2509400+414WP_006814675.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
EL244_RS115902509458..2510354-897WP_006814676.1Dyp-type peroxidase-
EL244_RS115952510569..2511153-585WP_039855044.1RpoE-regulated lipoprotein-
EL244_RS116002511235..2511666-432WP_006814678.1GNAT family acetyltransferase-
EL244_RS116052511802..2512719+918WP_006814679.1oxygen-dependent coproporphyrinogen oxidase-
EL244_RS116102512877..2514010+1134WP_126461052.1M4 family metallopeptidase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7064.36 Da        Isoelectric Point: 11.2336

>T287862 WP_071599550.1 NZ_LR134396:2508745-2508930 [Providencia rustigianii]
MKSSELIKLLEKNGWRLERIKGSHHQFSHPNFSIVITVPHPRKDLKIGTLNQILTVAKLKH

Download         Length: 186 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15388.27 Da        Isoelectric Point: 4.9767

>AT287862 WP_006814675.1 NZ_LR134396:2508987-2509400 [Providencia rustigianii]
MLYPAFIEIDSDGSASGWFPDIEGCTFAGDNIEDAYADAKSAIDVHFELLSEKGFKIPSPKSQHAHLQDTPDIYQKGIWL
LVDIDMDKYDGRAERVNITLPHRLLHRIDTLVKEHPEYGSRSGFIAAAARKELQKNS

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A379G4X3

References