Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2508745..2509400 Replicon chromosome
Accession NZ_LR134396
Organism Providencia rustigianii strain NCTC8113

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EL244_RS11580 Protein ID WP_071599550.1
Coordinates 2508745..2508930 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID D1P354
Locus tag EL244_RS11585 Protein ID WP_006814675.1
Coordinates 2508987..2509400 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL244_RS11560 2504658..2505746 - 1089 WP_126461046.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -
EL244_RS11565 2505749..2506609 - 861 WP_126461049.1 sulfate/thiosulfate ABC transporter permease CysW -
EL244_RS11570 2506609..2507439 - 831 WP_006814673.1 sulfate/thiosulfate ABC transporter permease CysT -
EL244_RS11575 2507439..2508461 - 1023 WP_115164490.1 sulfate ABC transporter substrate-binding protein -
EL244_RS11580 2508745..2508930 + 186 WP_071599550.1 type II toxin-antitoxin system HicA family toxin Toxin
EL244_RS11585 2508987..2509400 + 414 WP_006814675.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL244_RS11590 2509458..2510354 - 897 WP_006814676.1 Dyp-type peroxidase -
EL244_RS11595 2510569..2511153 - 585 WP_039855044.1 RpoE-regulated lipoprotein -
EL244_RS11600 2511235..2511666 - 432 WP_006814678.1 GNAT family acetyltransferase -
EL244_RS11605 2511802..2512719 + 918 WP_006814679.1 oxygen-dependent coproporphyrinogen oxidase -
EL244_RS11610 2512877..2514010 + 1134 WP_126461052.1 M4 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7064.36 Da        Isoelectric Point: 11.2336

>T287862 WP_071599550.1 NZ_LR134396:2508745-2508930 [Providencia rustigianii]
MKSSELIKLLEKNGWRLERIKGSHHQFSHPNFSIVITVPHPRKDLKIGTLNQILTVAKLKH

Download         Length: 186 bp

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15388.27 Da        Isoelectric Point: 4.9767

>AT287862 WP_006814675.1 NZ_LR134396:2508987-2509400 [Providencia rustigianii]
MLYPAFIEIDSDGSASGWFPDIEGCTFAGDNIEDAYADAKSAIDVHFELLSEKGFKIPSPKSQHAHLQDTPDIYQKGIWL
LVDIDMDKYDGRAERVNITLPHRLLHRIDTLVKEHPEYGSRSGFIAAAARKELQKNS

Download         Length: 414 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A379G4X3

References