Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1467916..1468615 Replicon chromosome
Accession NZ_LR134396
Organism Providencia rustigianii strain NCTC8113

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EL244_RS06550 Protein ID WP_126459605.1
Coordinates 1467916..1468302 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D1NZL2
Locus tag EL244_RS06555 Protein ID WP_006813433.1
Coordinates 1468295..1468615 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL244_RS06530 1463138..1463764 + 627 WP_172597543.1 protein phosphatase CheZ -
EL244_RS06535 1463916..1464263 - 348 WP_006813437.1 HNH nuclease YajD -
EL244_RS06540 1464534..1465685 + 1152 WP_006813436.1 flagellar type III secretion system protein FlhB -
EL244_RS06545 1465678..1467774 + 2097 WP_126459602.1 flagellar biosynthesis protein FlhA -
EL244_RS06550 1467916..1468302 + 387 WP_126459605.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL244_RS06555 1468295..1468615 + 321 WP_006813433.1 helix-turn-helix domain-containing protein Antitoxin
EL244_RS06560 1468653..1469093 - 441 WP_126459608.1 flagellar export chaperone FlgN -
EL244_RS06565 1469105..1469407 - 303 WP_006813431.1 anti-sigma-28 factor FlgM -
EL244_RS06570 1469618..1470286 - 669 WP_006813429.1 flagellar basal body P-ring formation protein FlgA -
EL244_RS06575 1470518..1470931 + 414 WP_006813427.1 flagellar basal body rod protein FlgB -
EL244_RS06580 1470937..1471341 + 405 WP_006813426.1 flagellar basal body rod protein FlgC -
EL244_RS06585 1471354..1472211 + 858 WP_115164158.1 flagellar basal-body rod modification protein -
EL244_RS06590 1472242..1473462 + 1221 WP_126459611.1 flagellar hook protein FlgE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14374.95 Da        Isoelectric Point: 10.1566

>T287859 WP_126459605.1 NZ_LR134396:1467916-1468302 [Providencia rustigianii]
MAIYKTKIFKSKLKKLELDEIDVLLAAKQVLSGCYEADLGGGVIKKRLAIQGVGKRAGIRTIIFYKQGSHLFFADGWSKS
RLASKGRKEIEDDDLESYKDIARILLNSDPMKIAHMLKTGYLIEVKNV

Download         Length: 387 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12111.11 Da        Isoelectric Point: 9.7949

>AT287859 WP_006813433.1 NZ_LR134396:1468295-1468615 [Providencia rustigianii]
MSNTMKELLEFAQGLEKIGVTDDIASRRIEARIKARELKEKFSALKPMTGEDIKRIREENNISQSSLALILNMTKESVSK
WERDEIKPNGAALRLLNLIEQKTLII

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB D1NZL2

References