Detailed information of TA system TA287858

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): sdenTA/AbiEii(toxin)
• Location: 1110859..1112289
• Replicon: chromosome
• Accession: NZ_LR134396
• Organism: Providencia rustigianii strain NCTC8113

Toxin (Protein)

• Gene name: sdenT
• Uniprot ID: -
• Locus tag: EL244_RS05015
• Protein ID: WP_126459198.1
• Coordinates: 1110859..1111749 (-)
• Length: 297 a.a.

Antitoxin (Protein)

• Gene name: sdenA
• Uniprot ID: D1NXR7
• Locus tag: EL244_RS05020
• Protein ID: WP_006812791.1
• Coordinates: 1111765..1112289 (-)
• Length: 175 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL244_RS05000	1107236..1107730	-	495	WP_006812795.1	DUF2569 domain-containing protein	-
EL244_RS05005	1107970..1108785	+	816	WP_126459195.1	sulfite exporter TauE/SafE family protein	-
EL244_RS05010	1108933..1110600	+	1668	WP_039854007.1	glutamine--tRNA ligase	-
EL244_RS05015	1110859..1111749	-	891	WP_126459198.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
EL244_RS05020	1111765..1112289	-	525	WP_006812791.1	hypothetical protein	Antitoxin
EL244_RS05025	1112464..1112859	-	396	WP_115164056.1	DUF5329 family protein	-
EL244_RS05030	1112970..1113653	-	684	WP_006812789.1	two-component system response regulator KdpE	-
EL244_RS05035	1113670..1116363	-	2694	WP_126459201.1	two-component system sensor histidine kinase KdpD	-
EL244_RS05040	1116372..1116965	-	594	WP_039854006.1	potassium-transporting ATPase subunit KdpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (36-267)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 297 a.a.
• Molecular weight: 34595.77 Da
• Isoelectric Point: 5.9362

>T287858 WP_126459198.1 NZ_LR134396:c1111749-1110859 [Providencia rustigianii]
MLKQQIRQIIQVNPDYAAITPVIEKEILHHDIMDVLIRQGAMQRLTFIDGTSLRMCYNSSRLSEDLDFNGGHDFKPTEFD
GLEFEIQKYIQNKYETDVWVNKPSEEKQGDTVSWKISIVKEANRPDLPRQKMHIDVCAIPSFDIEKRPLLNHYDIVVPTE
GILVPVQSLQETLADKLIALAYRARRIKPRDIWDIVWIKQRGISLSKTLVEKKLIARNKEIDDFHHAIAIQLNKLMQEDD
LRNDFNAEMSRFIPKQIKERTVDNPEYWAYVQTEVNDIVTELLNNIKPKNPFDMGL

Nucleotide

• Length: 891 bp

Antitoxin

Protein

• Length: 175 a.a.
• Molecular weight: 19427.73 Da
• Isoelectric Point: 10.0491

>AT287858 WP_006812791.1 NZ_LR134396:c1112289-1111765 [Providencia rustigianii]
MAKIDKLLSALASAVKAGGGIHSAAELAFMLGEPCNPTFRKFLTDSVKKGQLRRVVKGLYESVLTPPEPETAIYKIIKKL
RSNVLNYISLESQLSYTGNISQVIMGRVTVITKGRSGRFDTPYGVIEFIHTKKPIEQIAPNLYYDSDIKMYRANTAQAII
DLKHCQRNIHMLDL

Nucleotide

• Length: 525 bp

Structures

Antitoxin

• AlphaFold DB: A0A379G1B1