Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 855819..856462 Replicon chromosome
Accession NZ_LR134396
Organism Providencia rustigianii strain NCTC8113

Toxin (Protein)


Gene name Hha Uniprot ID D1P676
Locus tag EL244_RS03830 Protein ID WP_006815740.1
Coordinates 855819..856022 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D1P675
Locus tag EL244_RS03835 Protein ID WP_006815739.1
Coordinates 856094..856462 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL244_RS03810 851804..853588 + 1785 WP_126458871.1 SmdB family multidrug efflux ABC transporter permease/ATP-binding protein -
EL244_RS03815 853695..854561 - 867 WP_006815742.1 acyl-CoA thioesterase II -
EL244_RS03820 854804..855262 + 459 WP_126458874.1 YbaY family lipoprotein -
EL244_RS03830 855819..856022 - 204 WP_006815740.1 hemolysin expression modulator Hha Toxin
EL244_RS03835 856094..856462 - 369 WP_006815739.1 Hha toxicity modulator TomB Antitoxin
EL244_RS03840 856990..858366 - 1377 WP_126458877.1 murein transglycosylase D -
EL244_RS03845 858450..859202 - 753 WP_126458880.1 hydroxyacylglutathione hydrolase -
EL244_RS03850 859237..859962 + 726 WP_126458883.1 class I SAM-dependent methyltransferase -
EL244_RS03855 859971..860441 - 471 WP_006815735.1 ribonuclease HI -
EL244_RS03860 860496..861257 + 762 WP_006815734.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8087.38 Da        Isoelectric Point: 6.9770

>T287857 WP_006815740.1 NZ_LR134396:c856022-855819 [Providencia rustigianii]
MTKSDYLMRLRKCTTLETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14120.98 Da        Isoelectric Point: 4.3849

>AT287857 WP_006815739.1 NZ_LR134396:c856462-856094 [Providencia rustigianii]
MDEYSPKKHDIAELKYLCNSLNRDAISSLQKTTTHWINDLSSPLSVSLNELVEHITSFVWRFKIKYPKENLVISLVEEYL
DETYDLFGSPVITFSEITDWESMNQNLVAVLDDDLKCLTSKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379G0S0

Antitoxin

Source ID Structure
AlphaFold DB A0A379G117

References