Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 401041..401689 Replicon chromosome
Accession NZ_LR134395
Organism Haemophilus aegyptius strain NCTC8134

Toxin (Protein)


Gene name toxT Uniprot ID A0A0Y7JUP0
Locus tag EL190_RS02145 Protein ID WP_005694481.1
Coordinates 401041..401400 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag EL190_RS02150 Protein ID WP_005650837.1
Coordinates 401393..401689 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL190_RS02140 397696..400780 + 3085 Protein_409 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
EL190_RS02145 401041..401400 + 360 WP_005694481.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL190_RS02150 401393..401689 + 297 WP_005650837.1 helix-turn-helix transcriptional regulator Antitoxin
EL190_RS02155 401850..403766 + 1917 WP_006995317.1 ABC transporter ATP-binding protein -
EL190_RS02160 403776..404312 + 537 WP_006995316.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
EL190_RS02165 404328..404879 + 552 WP_006995315.1 Sua5/YciO/YrdC/YwlC family protein -
EL190_RS02170 404883..405689 + 807 WP_006995314.1 shikimate dehydrogenase -
EL190_RS02175 405701..406453 + 753 WP_006995313.1 DUF3800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(36-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-89)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 14321.67 Da        Isoelectric Point: 10.1408

>T287851 WP_005694481.1 NZ_LR134395:401041-401400 [Haemophilus aegyptius]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVKLLSELGTSVGKPYVKHLDGEIWELRPIRDRILFARLM
DGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Download         Length: 360 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11092.94 Da        Isoelectric Point: 10.3139

>AT287851 WP_005650837.1 NZ_LR134395:401393-401689 [Haemophilus aegyptius]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Y7JUP0

Antitoxin

Source ID Structure

References