Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 401041..401689 Replicon chromosome
Accession NZ_LR134395
Organism Haemophilus aegyptius strain NCTC8134

Toxin (Protein)


Gene name toxT Uniprot ID A0A0Y7JUP0
Locus tag EL190_RS02145 Protein ID WP_005694481.1
Coordinates 401041..401400 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag EL190_RS02150 Protein ID WP_005650837.1
Coordinates 401393..401689 (+) Length 99 a.a.

Genomic Context

EL190_RS02140EL190_RS02145EL190_RS02150EL190_RS02155EL190_RS02160EL190_RS02165EL190_RS02170EL190_RS02175
Location: 397696..400780 (3085 bp)
Type: Others
Protein ID: Protein_409
Location: 401041..401400 (360 bp)
Type: Toxin
Protein ID: WP_005694481.1
Location: 401393..401689 (297 bp)
Type: Antitoxin
Protein ID: WP_005650837.1
Location: 401850..403766 (1917 bp)
Type: Others
Protein ID: WP_006995317.1
Location: 403776..404312 (537 bp)
Type: Others
Protein ID: WP_006995316.1
Location: 404328..404879 (552 bp)
Type: Others
Protein ID: WP_006995315.1
Location: 404883..405689 (807 bp)
Type: Others
Protein ID: WP_006995314.1
Location: 405701..406453 (753 bp)
Type: Others
Protein ID: WP_006995313.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EL190_RS02140397696..400780+3085Protein_409TonB-dependent hemoglobin/transferrin/lactoferrin family receptor-
EL190_RS02145401041..401400+360WP_005694481.1type II toxin-antitoxin system RelE/ParE family toxinToxin
EL190_RS02150401393..401689+297WP_005650837.1helix-turn-helix transcriptional regulatorAntitoxin
EL190_RS02155401850..403766+1917WP_006995317.1ABC transporter ATP-binding protein-
EL190_RS02160403776..404312+537WP_006995316.1topoisomerase DNA-binding C4 zinc finger domain-containing protein-
EL190_RS02165404328..404879+552WP_006995315.1Sua5/YciO/YrdC/YwlC family protein-
EL190_RS02170404883..405689+807WP_006995314.1shikimate dehydrogenase-
EL190_RS02175405701..406453+753WP_006995313.1DUF3800 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(36-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-89)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 14321.67 Da        Isoelectric Point: 10.1408

>T287851 WP_005694481.1 NZ_LR134395:401041-401400 [Haemophilus aegyptius]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVKLLSELGTSVGKPYVKHLDGEIWELRPIRDRILFARLM
DGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Download         Length: 360 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11092.94 Da        Isoelectric Point: 10.3139

>AT287851 WP_005650837.1 NZ_LR134395:401393-401689 [Haemophilus aegyptius]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Y7JUP0

Antitoxin

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Source
ID
Structure
No matching records found

References