Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 423808..424635 | Replicon | |
| Accession | NC_020134 | ||
| Organism | Clostridium stercorarium subsp. stercorarium DSM 8532 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | CST_RS01800 | Protein ID | WP_015484857.1 |
| Coordinates | 423808..424272 (-) | Length | 155 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | L7VL72 |
| Locus tag | CST_RS01805 | Protein ID | WP_015358106.1 |
| Coordinates | 424294..424635 (-) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CST_RS01775 | 418897..419328 | + | 432 | WP_015358101.1 | hypothetical protein | - |
| CST_RS01780 | 420212..420343 | - | 132 | Protein_343 | helix-turn-helix domain-containing protein | - |
| CST_RS13170 | 420551..420769 | + | 219 | Protein_344 | helix-turn-helix domain-containing protein | - |
| CST_RS01785 | 420778..422004 | - | 1227 | WP_015358103.1 | IS256 family transposase | - |
| CST_RS13295 | 422065..422217 | + | 153 | Protein_346 | IS30 family transposase | - |
| CST_RS01795 | 422586..423803 | - | 1218 | WP_015358104.1 | site-specific integrase | - |
| CST_RS01800 | 423808..424272 | - | 465 | WP_015484857.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| CST_RS01805 | 424294..424635 | - | 342 | WP_015358106.1 | helix-turn-helix domain-containing protein | Antitoxin |
| CST_RS01810 | 424782..424982 | + | 201 | WP_015358107.1 | transcriptional regulator | - |
| CST_RS01815 | 425022..425216 | + | 195 | WP_015484858.1 | helix-turn-helix domain-containing protein | - |
| CST_RS01820 | 425238..425435 | + | 198 | WP_015358108.1 | hypothetical protein | - |
| CST_RS01825 | 425591..425770 | + | 180 | WP_015358109.1 | hypothetical protein | - |
| CST_RS01830 | 425829..426758 | + | 930 | WP_015358110.1 | YqaJ viral recombinase family protein | - |
| CST_RS01835 | 426773..427588 | + | 816 | WP_015358111.1 | recombination protein RecT | - |
| CST_RS01840 | 428019..428897 | + | 879 | WP_015358113.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 420620..460524 | 39904 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 17967.60 Da Isoelectric Point: 6.9505
>T28785 WP_015484857.1 NC_020134:c424272-423808 [Thermoclostridium stercorarium subsp. stercorarium DSM 8532]
MLYEFLLIKADNEGINVYEKEIGKLKGLYFDGNIIINSSIETNSEKACILAEELGHHYTTHGNILNQCKVENRKQERRAR
AWAYERLVSLNSLIEASKHCIRNRFELAEFLGVSERFIDEAIQYYKEKYGICHKVGDYIVYFEPLGVLKKVQKE
MLYEFLLIKADNEGINVYEKEIGKLKGLYFDGNIIINSSIETNSEKACILAEELGHHYTTHGNILNQCKVENRKQERRAR
AWAYERLVSLNSLIEASKHCIRNRFELAEFLGVSERFIDEAIQYYKEKYGICHKVGDYIVYFEPLGVLKKVQKE
Download Length: 465 bp
>T28785 NC_020134:c424272-423808 [Thermoclostridium stercorarium subsp. stercorarium DSM 8532]
TTGCTTTATGAATTTCTTCTCATCAAGGCCGACAACGAAGGTATAAATGTATATGAAAAGGAAATCGGGAAATTAAAAGG
ATTATACTTTGACGGAAATATAATAATTAATTCTTCAATCGAAACAAATTCTGAAAAAGCCTGTATTTTAGCCGAAGAAT
TGGGACATCATTATACGACCCATGGAAATATATTGAACCAATGTAAAGTAGAAAACAGAAAACAGGAACGTCGGGCCCGC
GCTTGGGCATACGAACGACTGGTAAGTTTGAATAGCCTGATAGAGGCATCTAAACATTGTATCAGAAATAGATTTGAGTT
AGCTGAATTTTTGGGTGTATCCGAACGTTTTATTGATGAGGCAATTCAATATTACAAAGAAAAGTATGGTATTTGCCACA
AAGTTGGAGATTACATAGTTTATTTTGAACCTTTAGGAGTTCTAAAAAAAGTACAAAAGGAGTGA
TTGCTTTATGAATTTCTTCTCATCAAGGCCGACAACGAAGGTATAAATGTATATGAAAAGGAAATCGGGAAATTAAAAGG
ATTATACTTTGACGGAAATATAATAATTAATTCTTCAATCGAAACAAATTCTGAAAAAGCCTGTATTTTAGCCGAAGAAT
TGGGACATCATTATACGACCCATGGAAATATATTGAACCAATGTAAAGTAGAAAACAGAAAACAGGAACGTCGGGCCCGC
GCTTGGGCATACGAACGACTGGTAAGTTTGAATAGCCTGATAGAGGCATCTAAACATTGTATCAGAAATAGATTTGAGTT
AGCTGAATTTTTGGGTGTATCCGAACGTTTTATTGATGAGGCAATTCAATATTACAAAGAAAAGTATGGTATTTGCCACA
AAGTTGGAGATTACATAGTTTATTTTGAACCTTTAGGAGTTCTAAAAAAAGTACAAAAGGAGTGA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12856.79 Da Isoelectric Point: 8.3707
>AT28785 WP_015358106.1 NC_020134:c424635-424294 [Thermoclostridium stercorarium subsp. stercorarium DSM 8532]
MAIGDRIKKLRIEKGMTQEELAKYIDSTKQTIYKYENNIVTNIPSDKIEKIAEALGTTPSYLMGWNDTASKNNVKKPITV
AAHIPDGVELTEEDIKQINDFIQFIISKKKDQK
MAIGDRIKKLRIEKGMTQEELAKYIDSTKQTIYKYENNIVTNIPSDKIEKIAEALGTTPSYLMGWNDTASKNNVKKPITV
AAHIPDGVELTEEDIKQINDFIQFIISKKKDQK
Download Length: 342 bp
>AT28785 NC_020134:c424635-424294 [Thermoclostridium stercorarium subsp. stercorarium DSM 8532]
TTGGCTATTGGTGATAGAATAAAAAAACTCAGAATAGAAAAAGGCATGACACAGGAAGAATTGGCCAAATATATTGATTC
CACCAAACAAACAATTTACAAATATGAAAATAACATTGTGACTAATATTCCCTCTGATAAGATTGAAAAAATTGCAGAGG
CATTAGGAACGACACCTTCTTATTTAATGGGCTGGAACGATACAGCTTCCAAAAATAATGTTAAAAAGCCCATCACTGTT
GCCGCACATATTCCTGATGGCGTTGAACTTACTGAGGAAGATATAAAACAAATCAATGACTTCATACAGTTCATTATTTC
AAAAAAGAAGGATCAAAAGTAA
TTGGCTATTGGTGATAGAATAAAAAAACTCAGAATAGAAAAAGGCATGACACAGGAAGAATTGGCCAAATATATTGATTC
CACCAAACAAACAATTTACAAATATGAAAATAACATTGTGACTAATATTCCCTCTGATAAGATTGAAAAAATTGCAGAGG
CATTAGGAACGACACCTTCTTATTTAATGGGCTGGAACGATACAGCTTCCAAAAATAATGTTAAAAAGCCCATCACTGTT
GCCGCACATATTCCTGATGGCGTTGAACTTACTGAGGAAGATATAAAACAAATCAATGACTTCATACAGTTCATTATTTC
AAAAAAGAAGGATCAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|