Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 423808..424635 Replicon
Accession NC_020134
Organism Clostridium stercorarium subsp. stercorarium DSM 8532

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag CST_RS01800 Protein ID WP_015484857.1
Coordinates 423808..424272 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID L7VL72
Locus tag CST_RS01805 Protein ID WP_015358106.1
Coordinates 424294..424635 (-) Length 114 a.a.

Genomic Context

CST_RS01775CST_RS13170CST_RS13295CST_RS01810CST_RS01815CST_RS01820CST_RS01825CST_RS01830CST_RS01835CST_RS01840CST_RS01780CST_RS01785CST_RS01795CST_RS01800CST_RS01805
Location: 418897..419328 (432 bp)
Type: Others
Protein ID: WP_015358101.1
Location: 420551..420769 (219 bp)
Type: Others
Protein ID: Protein_344
Location: 422065..422217 (153 bp)
Type: Others
Protein ID: Protein_346
Location: 424782..424982 (201 bp)
Type: Others
Protein ID: WP_015358107.1
Location: 425022..425216 (195 bp)
Type: Others
Protein ID: WP_015484858.1
Location: 425238..425435 (198 bp)
Type: Others
Protein ID: WP_015358108.1
Location: 425591..425770 (180 bp)
Type: Others
Protein ID: WP_015358109.1
Location: 425829..426758 (930 bp)
Type: Others
Protein ID: WP_015358110.1
Location: 426773..427588 (816 bp)
Type: Others
Protein ID: WP_015358111.1
Location: 428019..428897 (879 bp)
Type: Others
Protein ID: WP_015358113.1
Location: 420212..420343 (132 bp)
Type: Others
Protein ID: Protein_343
Location: 420778..422004 (1227 bp)
Type: Others
Protein ID: WP_015358103.1
Location: 422586..423803 (1218 bp)
Type: Others
Protein ID: WP_015358104.1
Location: 423808..424272 (465 bp)
Type: Toxin
Protein ID: WP_015484857.1
Location: 424294..424635 (342 bp)
Type: Antitoxin
Protein ID: WP_015358106.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CST_RS01775418897..419328+432WP_015358101.1hypothetical protein-
CST_RS01780420212..420343-132Protein_343helix-turn-helix domain-containing protein-
CST_RS13170420551..420769+219Protein_344helix-turn-helix domain-containing protein-
CST_RS01785420778..422004-1227WP_015358103.1IS256 family transposase-
CST_RS13295422065..422217+153Protein_346IS30 family transposase-
CST_RS01795422586..423803-1218WP_015358104.1site-specific integrase-
CST_RS01800423808..424272-465WP_015484857.1ImmA/IrrE family metallo-endopeptidaseToxin
CST_RS01805424294..424635-342WP_015358106.1helix-turn-helix domain-containing proteinAntitoxin
CST_RS01810424782..424982+201WP_015358107.1transcriptional regulator-
CST_RS01815425022..425216+195WP_015484858.1helix-turn-helix domain-containing protein-
CST_RS01820425238..425435+198WP_015358108.1hypothetical protein-
CST_RS01825425591..425770+180WP_015358109.1hypothetical protein-
CST_RS01830425829..426758+930WP_015358110.1YqaJ viral recombinase family protein-
CST_RS01835426773..427588+816WP_015358111.1recombination protein RecT-
CST_RS01840428019..428897+879WP_015358113.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--420620..46052439904


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(14-120)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17967.60 Da        Isoelectric Point: 6.9505

>T28785 WP_015484857.1 NC_020134:c424272-423808 [Thermoclostridium stercorarium subsp. stercorarium DSM 8532]
MLYEFLLIKADNEGINVYEKEIGKLKGLYFDGNIIINSSIETNSEKACILAEELGHHYTTHGNILNQCKVENRKQERRAR
AWAYERLVSLNSLIEASKHCIRNRFELAEFLGVSERFIDEAIQYYKEKYGICHKVGDYIVYFEPLGVLKKVQKE

Download         Length: 465 bp

>T28785 NC_020134:c424272-423808 [Thermoclostridium stercorarium subsp. stercorarium DSM 8532]
TTGCTTTATGAATTTCTTCTCATCAAGGCCGACAACGAAGGTATAAATGTATATGAAAAGGAAATCGGGAAATTAAAAGG
ATTATACTTTGACGGAAATATAATAATTAATTCTTCAATCGAAACAAATTCTGAAAAAGCCTGTATTTTAGCCGAAGAAT
TGGGACATCATTATACGACCCATGGAAATATATTGAACCAATGTAAAGTAGAAAACAGAAAACAGGAACGTCGGGCCCGC
GCTTGGGCATACGAACGACTGGTAAGTTTGAATAGCCTGATAGAGGCATCTAAACATTGTATCAGAAATAGATTTGAGTT
AGCTGAATTTTTGGGTGTATCCGAACGTTTTATTGATGAGGCAATTCAATATTACAAAGAAAAGTATGGTATTTGCCACA
AAGTTGGAGATTACATAGTTTATTTTGAACCTTTAGGAGTTCTAAAAAAAGTACAAAAGGAGTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12856.79 Da        Isoelectric Point: 8.3707

>AT28785 WP_015358106.1 NC_020134:c424635-424294 [Thermoclostridium stercorarium subsp. stercorarium DSM 8532]
MAIGDRIKKLRIEKGMTQEELAKYIDSTKQTIYKYENNIVTNIPSDKIEKIAEALGTTPSYLMGWNDTASKNNVKKPITV
AAHIPDGVELTEEDIKQINDFIQFIISKKKDQK

Download         Length: 342 bp

>AT28785 NC_020134:c424635-424294 [Thermoclostridium stercorarium subsp. stercorarium DSM 8532]
TTGGCTATTGGTGATAGAATAAAAAAACTCAGAATAGAAAAAGGCATGACACAGGAAGAATTGGCCAAATATATTGATTC
CACCAAACAAACAATTTACAAATATGAAAATAACATTGTGACTAATATTCCCTCTGATAAGATTGAAAAAATTGCAGAGG
CATTAGGAACGACACCTTCTTATTTAATGGGCTGGAACGATACAGCTTCCAAAAATAATGTTAAAAAGCCCATCACTGTT
GCCGCACATATTCCTGATGGCGTTGAACTTACTGAGGAAGATATAAAACAAATCAATGACTTCATACAGTTCATTATTTC
AAAAAAGAAGGATCAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBL7VL72

References