Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 956599..957228 Replicon chromosome
Accession NZ_LR134394
Organism Listeria ivanovii subsp. londoniensis strain NCTC12701

Toxin (Protein)


Gene name pemK Uniprot ID A0A097BBV7
Locus tag EL212_RS04480 Protein ID WP_025279828.1
Coordinates 956881..957228 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID H1GC21
Locus tag EL212_RS04475 Protein ID WP_003761302.1
Coordinates 956599..956877 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL212_RS04455 951937..953409 + 1473 WP_003719081.1 PH domain-containing protein -
EL212_RS04460 953532..954911 + 1380 WP_003719082.1 protoporphyrinogen oxidase -
EL212_RS04465 954913..955269 + 357 WP_003719083.1 holo-ACP synthase -
EL212_RS04470 955287..956393 + 1107 WP_038408703.1 alanine racemase -
EL212_RS04475 956599..956877 + 279 WP_003761302.1 CopG family ribbon-helix-helix protein Antitoxin
EL212_RS04480 956881..957228 + 348 WP_025279828.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL212_RS04485 957478..958314 + 837 WP_038406970.1 STAS domain-containing protein -
EL212_RS04490 958320..958676 + 357 WP_003719089.1 STAS domain-containing protein -
EL212_RS04495 958679..959089 + 411 WP_074673827.1 anti-sigma regulatory factor -
EL212_RS04500 959106..960110 + 1005 WP_003719091.1 PP2C family protein-serine/threonine phosphatase -
EL212_RS04505 960260..960604 + 345 WP_038406972.1 anti sigma b factor antagonist RsbV -
EL212_RS04510 960588..961061 + 474 WP_038406973.1 anti-sigma B factor RsbW -
EL212_RS04515 961039..961818 + 780 WP_003719094.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12829.90 Da        Isoelectric Point: 6.4735

>T287849 WP_025279828.1 NZ_LR134394:956881-957228 [Listeria ivanovii subsp. londoniensis]
MMVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIR
TIDKQRLTDKITHLDEELMVKVNQALEVSLGVVEF

Download         Length: 348 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10605.13 Da        Isoelectric Point: 4.2980

>AT287849 WP_003761302.1 NZ_LR134394:956599-956877 [Listeria ivanovii subsp. londoniensis]
VLEKEKRMIISVELTQEMVQELDVVVEKEKMGRSEVIMEATQQFLQEKRARELRDEMERGYAEMATINFAIACECTHVEA
EAEDRNISILGG

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097BBV7

Antitoxin

Source ID Structure
AlphaFold DB H1GC21

References