Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 49441..51038 Replicon chromosome
Accession NZ_LR134393
Organism Pseudomonas taetrolens strain NCTC8067

Toxin (Protein)


Gene name hipA Uniprot ID A0A0J6GTI8
Locus tag EL287_RS00235 Protein ID WP_048381606.1
Coordinates 49713..51038 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EL287_RS00230 Protein ID WP_048381608.1
Coordinates 49441..49716 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL287_RS00205 44814..45914 + 1101 WP_048381614.1 polyamine ABC transporter substrate-binding protein -
EL287_RS00210 45968..47515 - 1548 WP_048381613.1 PLP-dependent aminotransferase family protein -
EL287_RS00215 47605..48234 + 630 WP_048381611.1 FMN-binding negative transcriptional regulator -
EL287_RS00220 48239..48691 + 453 WP_048381610.1 GNAT family N-acetyltransferase -
EL287_RS00225 48705..49385 + 681 WP_048381609.1 GNAT family N-acetyltransferase -
EL287_RS00230 49441..49716 - 276 WP_048381608.1 helix-turn-helix domain-containing protein Antitoxin
EL287_RS00235 49713..51038 - 1326 WP_048381606.1 HipA domain-containing protein Toxin
EL287_RS00240 51261..53069 - 1809 WP_048381605.1 sodium-extruding oxaloacetate decarboxylase subunit alpha -
EL287_RS00245 53081..54496 - 1416 WP_048381600.1 acetyl-CoA carboxylase biotin carboxylase subunit -
EL287_RS00250 54687..55649 + 963 WP_048381599.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-369)

Antitoxin

Cro/C1-type helix-turn-helix domain

(27-80)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49001.72 Da        Isoelectric Point: 5.0869

>T287848 WP_048381606.1 NZ_LR134393:c51038-49713 [Pseudomonas taetrolens]
MFQLTLQLYSAGQWLDAMTLAFPEPEKGLDGPCRFGYKQDYLLDNLGAIDSPFAASVSACVPLEWDARHTKQAPAFLHDI
APAGAAKKVLIKQIGREKPEHLSDDLFLLGRSTPAPIGHLRIKESFEQLDQRQAMGFSREDVIVRDNSFLEYAHEQGAAI
GGATGAGGEAPKLLMAEGADGLLYPDATLADAQVKQHWFIKFARNQAFERDQVILRSEFLYYQALQALGIETVPAQGLAL
EEGRKPSLWMQRFDRHIEAQGVQRYAVESIYSLAQVTEPGSTMTHLEVVELLATLWTQAGQQAQIPDLVAEYLRRDLLNK
ILGNSDNHGRNTAIIRGSDSFRLAPIYDLAPMVMDDEGITRTTKWPLAIERAGAVDWRAACDSLRGVIDPQLAFDRLRHD
AQQLLALPDLLSASGLPDVTMNHPQIALRNLDQRLQEWGLK

Download         Length: 1326 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10401.16 Da        Isoelectric Point: 10.6965

>AT287848 WP_048381608.1 NZ_LR134393:c49716-49441 [Pseudomonas taetrolens]
MTLSIDVRQAKIQSIEDDLAQGKITLGEAVKRFRVDVTQLQQTQYARMCKISVRTLIQIEHDEGNPTLKSLNAVFKPFGL
QMGVVRRPRKF

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J6GTI8

Antitoxin

Source ID Structure

References