Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-HTH_XRE
Location 1117683..1118983 Replicon chromosome
Accession NZ_LR134385
Organism Gardnerella vaginalis strain NCTC10287

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag EL180_RS04725 Protein ID WP_004113001.1
Coordinates 1118174..1118983 (+) Length 270 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID S4HGB9
Locus tag EL180_RS04720 Protein ID WP_004113003.1
Coordinates 1117683..1118156 (+) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL180_RS04705 1113841..1114851 - 1011 WP_004116755.1 UDP-glucose 4-epimerase GalE -
EL180_RS04710 1115709..1117145 + 1437 WP_009994216.1 hypothetical protein -
EL180_RS04720 1117683..1118156 + 474 WP_004113003.1 helix-turn-helix domain-containing protein Antitoxin
EL180_RS04725 1118174..1118983 + 810 WP_004113001.1 zeta toxin family protein Toxin
EL180_RS04730 1119494..1120453 - 960 WP_004112999.1 aldose 1-epimerase family protein -
EL180_RS04735 1120501..1121001 - 501 WP_004112997.1 Cys-tRNA(Pro) deacylase -
EL180_RS04740 1121112..1122167 - 1056 WP_004112995.1 type I glyceraldehyde-3-phosphate dehydrogenase -
EL180_RS04745 1122343..1123080 - 738 WP_004112993.1 thiamine diphosphokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(34-221)

Antitoxin

Cro/C1-type helix-turn-helix domain

(6-59)


Sequences

Toxin        


Download         Length: 270 a.a.        Molecular weight: 30905.69 Da        Isoelectric Point: 8.9574

>T287846 WP_004113001.1 NZ_LR134385:1118174-1118983 [Gardnerella vaginalis]
MGKCDFAMVIEDFSEEYFTHCLLRNLRSLQMYKHADLHPKAVLLGGQSGAGKTTIHVIKQKEFNGNIIILDADSYRTQHP
YYCELLDKYGKESVKYTSAFSAKMVRSLIDELSSKKYNLIIEGTLRSVEVPSSTAKMLIDRGYRISLAVIATKPELSWIS
TLIRYREMYLEDPKSARATPKDHHDNIVNNIVDNLLKLEQSKIFDRIQIYKRDEKCIYDSDSYKNSPNITAASVLKEVLF
GKKTIDEKKLICHAKNRLNELDKLIDKSL

Download         Length: 810 bp

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 18016.48 Da        Isoelectric Point: 5.3394

>AT287846 WP_004113003.1 NZ_LR134385:1117683-1118156 [Gardnerella vaginalis]
MVSVNIRALRRSKKITQQELAEALGVSRNSIVRYENGTSAISTRLIDKICDKFKVSLFDIVHEKELSASDKYDLNMKIEV
LKERGALLLARLYKYEDSMNIQFDDSSNAWIAISDDLSDVINTKIYTSTNFEDINRYIGYLDGIERLLEYVSCNKNS

Download         Length: 474 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S4HGB9

References