Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 4065172..4065745 Replicon chromosome
Accession NZ_LR134382
Organism Bordetella hinzii strain NCTC13199

Toxin (Protein)


Gene name relE Uniprot ID W5IUR0
Locus tag EL326_RS19215 Protein ID WP_009618209.1
Coordinates 4065172..4065459 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EL326_RS19220 Protein ID WP_060833063.1
Coordinates 4065446..4065745 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL326_RS19190 4060786..4062828 - 2043 WP_060833067.1 DNA topoisomerase III -
EL326_RS19195 4063124..4063507 - 384 WP_060833066.1 single-stranded DNA-binding protein -
EL326_RS19200 4063504..4064052 - 549 WP_060833065.1 DUF3158 family protein -
EL326_RS19205 4064049..4064828 - 780 WP_060833064.1 TIGR03761 family integrating conjugative element protein -
EL326_RS19210 4064952..4065143 - 192 WP_011805449.1 hypothetical protein -
EL326_RS19215 4065172..4065459 - 288 WP_009618209.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL326_RS19220 4065446..4065745 - 300 WP_060833063.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EL326_RS19225 4065873..4067066 - 1194 WP_060833062.1 hypothetical protein -
EL326_RS19230 4067069..4067629 - 561 WP_020651215.1 DUF2857 domain-containing protein -
EL326_RS19235 4067647..4069305 - 1659 WP_060833061.1 ParB N-terminal domain-containing protein -
EL326_RS19240 4069298..4069546 - 249 WP_020651217.1 hypothetical protein -
EL326_RS19245 4069530..4070396 - 867 WP_060833060.1 ParA family protein -
EL326_RS19250 4070438..4070656 - 219 WP_060833059.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-54)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10854.46 Da        Isoelectric Point: 8.4628

>T287843 WP_009618209.1 NZ_LR134382:c4065459-4065172 [Bordetella hinzii]
VRVLEWREAARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPERPKLYRPGRVAGTREMVVRANYVVVYMEDTRAVSI
LRVLHAAQQWPPARE

Download         Length: 288 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10875.53 Da        Isoelectric Point: 9.8595

>AT287843 WP_060833063.1 NZ_LR134382:c4065745-4065446 [Bordetella hinzii]
MAAQTSMLHIRVDDKLKADAAEKLAGVGLTVSDAVRILLTRVVKEGALPAGLTADPEAYDAWFRAKVQEALADTRPPVRH
QQVMDEAQALIDRKRRART

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R9QF16

Antitoxin

Source ID Structure

References