Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1186419..1186986 Replicon chromosome
Accession NZ_LR134379
Organism Slackia heliotrinireducens strain NCTC11029

Toxin (Protein)


Gene name relE Uniprot ID C7N5J1
Locus tag EL225_RS05215 Protein ID WP_012798279.1
Coordinates 1186705..1186986 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C7N5J0
Locus tag EL225_RS05210 Protein ID WP_012798278.1
Coordinates 1186419..1186697 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL225_RS05185 1182016..1182903 + 888 WP_012798273.1 proline iminopeptidase-family hydrolase -
EL225_RS05190 1183161..1183652 + 492 WP_012798274.1 RNA polymerase sigma factor -
EL225_RS05195 1183649..1184764 + 1116 WP_012798275.1 zf-HC2 domain-containing protein -
EL225_RS05200 1184922..1185131 + 210 WP_012798276.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
EL225_RS05205 1185128..1186318 + 1191 WP_012798277.1 glycosyltransferase MGT family -
EL225_RS05210 1186419..1186697 + 279 WP_012798278.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EL225_RS05215 1186705..1186986 + 282 WP_012798279.1 type II toxin-antitoxin system YafQ family toxin Toxin
EL225_RS05220 1187285..1187485 - 201 WP_041422733.1 TM2 domain-containing protein -
EL225_RS05225 1187744..1188133 + 390 WP_012798281.1 (deoxy)nucleoside triphosphate pyrophosphohydrolase -
EL225_RS05230 1188139..1191063 - 2925 WP_012798282.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10758.40 Da        Isoelectric Point: 9.0911

>T287840 WP_012798279.1 NZ_LR134379:1186705-1186986 [Slackia heliotrinireducens]
MSLKLVPTSQFKKDYKRAKKRGLDMRKLQAVLDKLCAEEPLDERHRDHALSGNYIGFRECHVSPDWLLIYAIDKGRLILT
ASRTGTHSDLFDE

Download         Length: 282 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10017.40 Da        Isoelectric Point: 4.5680

>AT287840 WP_012798278.1 NZ_LR134379:1186419-1186697 [Slackia heliotrinireducens]
MAKTATINMRVNPEVKSSAETIFASLGMTLTEAINVFLHKSVMEGGLPFDVRQPRYNAETEAAMQEARDIMNGKAETDTF
DSAAAMFAALDK

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C7N5J1

Antitoxin

Source ID Structure
AlphaFold DB C7N5J0

References