Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5256751..5257390 Replicon chromosome
Accession NC_020133
Organism Mycobacterium liflandii 128FXT

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID L7VCR2
Locus tag MULP_RS22640 Protein ID WP_015357076.1
Coordinates 5256751..5257197 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID B2HEJ8
Locus tag MULP_RS22645 Protein ID WP_011738542.1
Coordinates 5257202..5257390 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MULP_RS22615 5251926..5253446 + 1521 WP_015357073.1 carotenoid oxygenase family protein -
MULP_RS22620 5253463..5253936 + 474 WP_012396158.1 VOC family protein -
MULP_RS22625 5253942..5254376 - 435 WP_012396159.1 hypothetical protein -
MULP_RS22630 5254447..5255220 - 774 WP_015357074.1 VOC family protein -
MULP_RS22635 5255386..5256639 + 1254 WP_015357075.1 hypothetical protein -
MULP_RS22640 5256751..5257197 - 447 WP_015357076.1 SRPBCC family protein Toxin
MULP_RS22645 5257202..5257390 - 189 WP_011738542.1 antitoxin Antitoxin
MULP_RS22650 5257492..5258586 - 1095 WP_193376239.1 hypothetical protein -
MULP_RS31990 5258643..5259008 - 366 WP_193376240.1 hypothetical protein -
MULP_RS29250 5259164..5260149 - 986 Protein_4655 ISAs1 family transposase -
MULP_RS31050 5260149..5260404 - 256 Protein_4656 transposase -
MULP_RS31055 5260434..5262180 - 1747 Protein_4657 PPE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 5259446..5259961 515


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 15861.43 Da        Isoelectric Point: 8.6574

>T28784 WP_015357076.1 NC_020133:c5257197-5256751 [Mycobacterium liflandii 128FXT]
MAKLSGSIDVPLSPDEAWMHASDLSRFKEWLTIHRVWRSTLPETLEKGAVVESIVQVKGMHNRIKWTIVRYQPPEGMTLN
GDGVGGVKVKLMAKVAAGEEGSIVSFDVHLGGPALFGPIGMVVAAALRSDINASLRNFVTVFAPPAAG

Download         Length: 447 bp

>T28784 NC_020133:c5257197-5256751 [Mycobacterium liflandii 128FXT]
ATGGCGAAACTTTCCGGGTCGATCGACGTGCCGCTGTCTCCGGACGAGGCATGGATGCACGCATCCGATCTCTCCCGCTT
CAAGGAGTGGCTGACGATCCACCGAGTGTGGCGCAGCACGTTGCCCGAAACCCTCGAAAAGGGTGCGGTCGTCGAATCAA
TCGTGCAGGTCAAGGGCATGCACAACCGCATCAAATGGACCATCGTGCGCTACCAGCCGCCGGAAGGCATGACCCTCAAC
GGTGACGGGGTCGGCGGCGTCAAGGTCAAGCTGATGGCCAAGGTTGCAGCCGGAGAAGAAGGCTCGATCGTCAGCTTCGA
CGTGCACCTTGGTGGGCCGGCTCTGTTCGGTCCGATCGGCATGGTCGTCGCCGCGGCGCTGCGCAGCGATATCAACGCAT
CGCTGCGGAACTTCGTCACCGTATTCGCCCCGCCGGCTGCCGGCTAA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6586.35 Da        Isoelectric Point: 4.7205

>AT28784 WP_011738542.1 NC_020133:c5257390-5257202 [Mycobacterium liflandii 128FXT]
MGILDKAKDLLAQNADKVETVIDKAGEFVDEKTEGKYSDTIHKVQEGAKKVAGPGAAGEQQN

Download         Length: 189 bp

>AT28784 NC_020133:c5257390-5257202 [Mycobacterium liflandii 128FXT]
ATGGGAATCCTGGACAAGGCGAAAGACCTGCTGGCGCAGAACGCCGACAAGGTCGAGACGGTGATCGACAAGGCCGGCGA
ATTCGTCGACGAGAAGACCGAAGGGAAGTACTCCGACACCATCCACAAGGTGCAAGAGGGGGCCAAGAAAGTCGCTGGTC
CCGGCGCCGCGGGCGAGCAGCAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XZB0

Antitoxin

Source ID Structure
AlphaFold DB A0A7I7LB02

References