Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2849671..2850311 Replicon chromosome
Accession NZ_LR134378
Organism Lautropia mirabilis strain NCTC12852

Toxin (Protein)


Gene name vapC Uniprot ID E7RTK5
Locus tag EL249_RS11705 Protein ID WP_005672112.1
Coordinates 2849931..2850311 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EL249_RS11700 Protein ID WP_005672114.1
Coordinates 2849671..2849934 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL249_RS11680 2848427..2849005 - 579 WP_005672118.1 NUDIX hydrolase -
EL249_RS11690 2849145..2849435 - 291 WP_005672116.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
EL249_RS11700 2849671..2849934 + 264 WP_005672114.1 DUF2191 domain-containing protein Antitoxin
EL249_RS11705 2849931..2850311 + 381 WP_005672112.1 PIN domain-containing protein Toxin
EL249_RS11710 2850343..2850951 - 609 WP_005672111.1 alpha/beta hydrolase -
EL249_RS11715 2851166..2853001 + 1836 WP_005672110.1 monovalent cation:proton antiporter-2 (CPA2) family protein -
EL249_RS11720 2853014..2853721 + 708 WP_005672108.1 YafY family transcriptional regulator -
EL249_RS11725 2853929..2854594 + 666 WP_005672107.1 glutathione S-transferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14263.62 Da        Isoelectric Point: 7.0389

>T287839 WP_005672112.1 NZ_LR134378:2849931-2850311 [Lautropia mirabilis]
MTTRAILVDSSVWVDHFRHGNEALTTLLHQDRVLVHPFVIGEIACGTPPDRTRVLAWLAELRSTQICSLNELMAFIERHR
LYGLGCGLVDLMLLASTLMTENALLWTLDRRLNSLAERFGIAHTVR

Download         Length: 381 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9499.69 Da        Isoelectric Point: 4.7066

>AT287839 WP_005672114.1 NZ_LR134378:2849671-2849934 [Lautropia mirabilis]
MRTTVTLDDALYEQALAVADPDMDKADLFREAVKTFVRIQSAKRLAALGGSMPDMQLPPRRSHSDDPASIQAQPATSRNE
DGFPSLP

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E7RTK5

Antitoxin

Source ID Structure

References