Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2690055..2690677 Replicon chromosome
Accession NZ_LR134378
Organism Lautropia mirabilis strain NCTC12852

Toxin (Protein)


Gene name hicA Uniprot ID E7RTZ0
Locus tag EL249_RS11035 Protein ID WP_005672357.1
Coordinates 2690055..2690237 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID E7RTY9
Locus tag EL249_RS11040 Protein ID WP_005672355.1
Coordinates 2690258..2690677 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL249_RS11005 2685770..2686423 - 654 WP_005672367.1 DUF799 family lipoprotein -
EL249_RS11010 2686420..2686839 - 420 WP_005672366.1 DUF4810 domain-containing protein -
EL249_RS11015 2686850..2687521 - 672 WP_040529635.1 CsgG/HfaB family protein -
EL249_RS11020 2687707..2687955 + 249 WP_005672363.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
EL249_RS11025 2687952..2688338 + 387 WP_005672361.1 type II toxin-antitoxin system VapC family toxin -
EL249_RS11030 2688470..2689756 - 1287 WP_005672358.1 glutamate-1-semialdehyde 2,1-aminomutase -
EL249_RS11035 2690055..2690237 + 183 WP_005672357.1 type II toxin-antitoxin system HicA family toxin Toxin
EL249_RS11040 2690258..2690677 + 420 WP_005672355.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL249_RS11045 2690745..2691875 - 1131 WP_005672352.1 molecular chaperone DnaJ -
EL249_RS11050 2692066..2694021 - 1956 WP_005672350.1 molecular chaperone DnaK -
EL249_RS11055 2694251..2694988 - 738 WP_083799601.1 nucleotide exchange factor GrpE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6698.85 Da        Isoelectric Point: 11.3859

>T287838 WP_005672357.1 NZ_LR134378:2690055-2690237 [Lautropia mirabilis]
MGSKELIKLIEAHGWHLVATRGSHRQYKHPTLPGRVTIPHPNKDLPRGTVQSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15473.28 Da        Isoelectric Point: 4.3475

>AT287838 WP_005672355.1 NZ_LR134378:2690258-2690677 [Lautropia mirabilis]
MLIPVAIHKDTDSLYGVTVPDIPGCFSAGETIEEALSNTREAIVFHLEGMLEDGEAVTVSTRQIEELAQEADYAGATWAL
IDVDLQRLSLKQTRFNVSWPEYLLARIDAYAEAHHETRSGLLAKAAERYLSEQRAHETN

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References