Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2079862..2080504 Replicon chromosome
Accession NZ_LR134378
Organism Lautropia mirabilis strain NCTC12852

Toxin (Protein)


Gene name vapC Uniprot ID E7RVW0
Locus tag EL249_RS08450 Protein ID WP_005673122.1
Coordinates 2080085..2080504 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A930GJP2
Locus tag EL249_RS08445 Protein ID WP_040531012.1
Coordinates 2079862..2080098 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL249_RS08425 2075342..2077753 + 2412 WP_005673128.1 phosphoenolpyruvate synthase -
EL249_RS08430 2078163..2078636 + 474 WP_040531014.1 NfeD family protein -
EL249_RS08440 2078818..2079750 + 933 WP_005673124.1 SPFH/Band 7/PHB domain protein -
EL249_RS08445 2079862..2080098 + 237 WP_040531012.1 DNA-binding protein Antitoxin
EL249_RS08450 2080085..2080504 + 420 WP_005673122.1 type II toxin-antitoxin system VapC family toxin Toxin
EL249_RS08455 2080566..2082092 - 1527 WP_197721579.1 glycoside hydrolase family 32 protein -
EL249_RS08460 2082667..2082888 + 222 WP_126348350.1 RcnB family protein -
EL249_RS08465 2082944..2084959 - 2016 WP_005673119.1 DUF3616 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15711.91 Da        Isoelectric Point: 6.6075

>T287837 WP_005673122.1 NZ_LR134378:2080085-2080504 [Lautropia mirabilis]
MYLIDTNVISEARKGRRANAGVQAFFREAAEQGSALYLSVITLGELRRGVDLIRHRGDHIQSRLLDDWLTLIVEQHHDRI
LPIDTEAALLWGRLRVPHHEHAIDKLIAATAWVNGLTLVTRNVSDFTETSVPLLNPFTD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8581.64 Da        Isoelectric Point: 4.7483

>AT287837 WP_040531012.1 NZ_LR134378:2079862-2080098 [Lautropia mirabilis]
MTSLLVRGLDESLVQALKQRAAANGRSAEAEHRAILLETLQRPPRKPLAEILASMPDVGLDSDFERQQDDGQSAHVFD

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E7RVW0

Antitoxin

Source ID Structure

References