Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-stbD/ParE(toxin)
Location 1171433..1171968 Replicon chromosome
Accession NZ_LR134378
Organism Lautropia mirabilis strain NCTC12852

Toxin (Protein)


Gene name relE Uniprot ID E7RYC5
Locus tag EL249_RS04775 Protein ID WP_005674013.1
Coordinates 1171433..1171717 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID E7RYC4
Locus tag EL249_RS04780 Protein ID WP_005674012.1
Coordinates 1171714..1171968 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL249_RS04760 1166905..1168395 + 1491 WP_040531585.1 M48 family metalloprotease -
EL249_RS04765 1168402..1170054 - 1653 WP_005674015.1 DUF3459 domain-containing protein -
EL249_RS04770 1170051..1171340 - 1290 WP_005674014.1 ABC transporter substrate-binding protein -
EL249_RS04775 1171433..1171717 - 285 WP_005674013.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL249_RS04780 1171714..1171968 - 255 WP_005674012.1 hypothetical protein Antitoxin
EL249_RS04785 1171992..1172429 - 438 WP_050781906.1 DUF3225 domain-containing protein -
EL249_RS04790 1172485..1172688 - 204 WP_005674010.1 zinc-finger domain-containing protein -
EL249_RS04795 1172926..1173852 - 927 WP_005674008.1 branched-chain amino acid transaminase -
EL249_RS04800 1174065..1176881 - 2817 WP_005674007.1 bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11016.00 Da        Isoelectric Point: 10.6292

>T287835 WP_005674013.1 NZ_LR134378:c1171717-1171433 [Lautropia mirabilis]
MKYQLTFNPQALKEFRKLGANIANQFLDKLEERLQNPKVPSARLIGMADCYKIKLRSSGYRLVYQVQDEKIIVQVIAVGK
RERMEVYQKAARRL

Download         Length: 285 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9506.77 Da        Isoelectric Point: 4.0259

>AT287835 WP_005674012.1 NZ_LR134378:c1171968-1171714 [Lautropia mirabilis]
MPSLILTDTVASLAELKEAPLETFSAADGHAIAILDKDKPAFYCVSPELYEYFMELAEDAELTRIVEERQHEEPIPVELE
SLRR

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References