Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1079460..1080133 Replicon chromosome
Accession NZ_LR134378
Organism Lautropia mirabilis strain NCTC12852

Toxin (Protein)


Gene name vapC Uniprot ID E7RYK3
Locus tag EL249_RS04375 Protein ID WP_005674101.1
Coordinates 1079460..1079882 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID E7RYK2
Locus tag EL249_RS04380 Protein ID WP_005674100.1
Coordinates 1079879..1080133 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL249_RS04355 1074778..1075449 - 672 WP_005674105.1 molybdate ABC transporter permease subunit -
EL249_RS04360 1075462..1076223 - 762 WP_040530017.1 molybdate ABC transporter substrate-binding protein -
EL249_RS04365 1076438..1078360 + 1923 WP_005674103.1 TonB-dependent receptor -
EL249_RS04370 1078417..1079475 - 1059 WP_005674102.1 alpha/beta hydrolase -
EL249_RS04375 1079460..1079882 - 423 WP_005674101.1 type II toxin-antitoxin system VapC family toxin Toxin
EL249_RS04380 1079879..1080133 - 255 WP_005674100.1 hypothetical protein Antitoxin
EL249_RS04385 1080270..1081577 - 1308 WP_040531651.1 pyridoxal phosphate-dependent aminotransferase -
EL249_RS04390 1081755..1082252 - 498 WP_040530014.1 thiol peroxidase -
EL249_RS04395 1082409..1084016 - 1608 WP_005674097.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15257.72 Da        Isoelectric Point: 6.7543

>T287834 WP_005674101.1 NZ_LR134378:c1079882-1079460 [Lautropia mirabilis]
MILLDTNVISEPMRREPEARVLAWLDRQPSETLFLSAITVAEIRKGIALLPAGKRQTLLAERLDKLLLPMFHGRILPFDI
HTTPAYASVIAHAAAAGCTIAAADGFIAAIALQHHFSVATRDTHPFQAAGLDVINPWTTD

Download         Length: 423 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9124.37 Da        Isoelectric Point: 5.1255

>AT287834 WP_005674100.1 NZ_LR134378:c1080133-1079879 [Lautropia mirabilis]
MAMLTVRNLPDEVHRALKARAASRGHSTEAEVRAILADAVKPAERIRLGSLLAGIGQEVGLTDEEFAIFENVRDRTSAPT
VDLE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E7RYK3

Antitoxin

Source ID Structure

References