Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 696511..697151 Replicon chromosome
Accession NZ_LR134378
Organism Lautropia mirabilis strain NCTC12852

Toxin (Protein)


Gene name VapC1 Uniprot ID -
Locus tag EL249_RS02795 Protein ID WP_197721597.1
Coordinates 696511..696909 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag EL249_RS02800 Protein ID WP_040531898.1
Coordinates 696915..697151 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL249_RS02775 693188..693715 - 528 WP_005674482.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
EL249_RS02780 694085..694857 - 773 Protein_541 HipA domain-containing protein -
EL249_RS02785 694807..695031 + 225 WP_083799546.1 helix-turn-helix domain-containing protein -
EL249_RS02790 695024..696442 + 1419 WP_083799545.1 zinc ribbon domain-containing protein -
EL249_RS02795 696511..696909 - 399 WP_197721597.1 type II toxin-antitoxin system VapC family toxin Toxin
EL249_RS02800 696915..697151 - 237 WP_040531898.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EL249_RS02805 697206..697394 + 189 WP_197721598.1 hypothetical protein -
EL249_RS02810 697399..698460 - 1062 WP_005674476.1 NAD(P)-dependent alcohol dehydrogenase -
EL249_RS02815 698484..699443 - 960 WP_126348062.1 hypothetical protein -
EL249_RS02820 699756..700397 - 642 WP_005674472.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-122)

Antitoxin

SpoVT-AbrB domain

(6-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15295.37 Da        Isoelectric Point: 7.9466

>T287833 WP_197721597.1 NZ_LR134378:c696909-696511 [Lautropia mirabilis]
MLDTNIIIYLMKNRPESVARKISSLAPHDRIVMSFVTYGELLQGAEGSRDRKKSHDNIRRITQRIQILYPDENTCIHYGH
WAETLKRQGRPIGNNDLWIACHALSAGATLVTHNSREFARIEDLNWQDWVEP

Download         Length: 399 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8813.93 Da        Isoelectric Point: 3.9937

>AT287833 WP_040531898.1 NZ_LR134378:c697151-696915 [Lautropia mirabilis]
MLTKVFQSGNSQAVRIPVDFRLDGDTVEIMRAENGDLILRPVIDKGEAFLDLFSGFDESFIQALEDRDMTPPQDRDPL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References