Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2108438..2109075 Replicon chromosome
Accession NZ_LR134375
Organism Veillonella dispar strain NCTC11831

Toxin (Protein)


Gene name vapC Uniprot ID C4FMJ6
Locus tag EL171_RS09865 Protein ID WP_005384837.1
Coordinates 2108665..2109075 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C4FMM5
Locus tag EL171_RS09860 Protein ID WP_005384838.1
Coordinates 2108438..2108668 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL171_RS09850 2105983..2106840 + 858 WP_024063815.1 methylenetetrahydrofolate reductase -
EL171_RS09855 2106988..2107740 - 753 WP_005384840.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
EL171_RS09860 2108438..2108668 + 231 WP_005384838.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EL171_RS09865 2108665..2109075 + 411 WP_005384837.1 type II toxin-antitoxin system VapC family toxin Toxin
EL171_RS09870 2109153..2111024 - 1872 WP_005384835.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG -
EL171_RS09875 2111138..2112523 - 1386 WP_005384833.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
EL171_RS09880 2112713..2113501 - 789 WP_005384831.1 protein jag -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(9-44)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15333.83 Da        Isoelectric Point: 7.3820

>T287832 WP_005384837.1 NZ_LR134375:2108665-2109075 [Veillonella dispar]
MKYMLDTNICIYAIKQEPEVVLQKILKHHPSDICISSITYAELMHGVEKSQSKDKNRLALTLLLSPIQIIDFDSHAAEEY
GKIKADLQSQGKIIGPMDLLIASHAKSKGLTIVTNNTKEFKRVNQLEVEDWSKPLS

Download         Length: 411 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8660.82 Da        Isoelectric Point: 4.4217

>AT287832 WP_005384838.1 NZ_LR134375:2108438-2108668 [Veillonella dispar]
MTTAKLFENGRSQAVRLPKEFRFNGDEVIINKIGNVVLLMPKDDEWAGFVAGLSLFTDDFMCNGREDIDHQEREAL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C4FMJ6

Antitoxin

Source ID Structure
AlphaFold DB A0A2S7YY19

References