Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafQ-relB/YafQ-DinJ
Location 105984..106544 Replicon chromosome
Accession NZ_LR134375
Organism Veillonella dispar strain NCTC11831

Toxin (Protein)


Gene name yafQ Uniprot ID C4FRV2
Locus tag EL171_RS00375 Protein ID WP_005387420.1
Coordinates 105984..106256 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C4FRV3
Locus tag EL171_RS00380 Protein ID WP_005387422.1
Coordinates 106263..106544 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL171_RS00345 101250..101990 + 741 WP_005387396.1 ABC transporter ATP-binding protein -
EL171_RS00350 102094..102588 + 495 WP_005387397.1 GyrI-like domain-containing protein -
EL171_RS00355 102735..103727 + 993 WP_005387399.1 virulence RhuM family protein -
EL171_RS00360 103752..104225 + 474 WP_005387404.1 HXXEE domain-containing protein -
EL171_RS00365 104404..105342 + 939 WP_005387412.1 IS30 family transposase -
EL171_RS00375 105984..106256 - 273 WP_005387420.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
EL171_RS00380 106263..106544 - 282 WP_005387422.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EL171_RS00385 106729..107361 + 633 WP_005387423.1 hypothetical protein -
EL171_RS00390 107749..108156 + 408 WP_009351901.1 hypothetical protein -
EL171_RS00395 108511..109631 + 1121 Protein_73 IS1249 family transposase -
EL171_RS00400 109798..111006 + 1209 WP_005387431.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 109071..109631 560


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-90)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10492.23 Da        Isoelectric Point: 9.7293

>T287830 WP_005387420.1 NZ_LR134375:c106256-105984 [Veillonella dispar]
MLRLVLSNKFKKDLKCSKKRGKDLNKLYSIITKLQNQTLLDPSYKDHPLTGNYEGFRELHVEPDWLLIYAIKDDILVLSL
TRTGSHSDLF

Download         Length: 273 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10173.73 Da        Isoelectric Point: 5.0931

>AT287830 WP_005387422.1 NZ_LR134375:c106544-106263 [Veillonella dispar]
MAKTASISLRIEPAVKAQLEALYASFGISVTDAINIFLHTSLMEGGFPFQPKQPRYNAETEAAIQETKDILAGKIKAKSY
ANVKEMIEDLGLE

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C4FRV2

Antitoxin

Source ID Structure
AlphaFold DB A0A2S7ZR52

References