Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3375370..3375990 Replicon chromosome
Accession NZ_LR134373
Organism Yersinia pseudotuberculosis strain NCTC10275

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag EL213_RS15370 Protein ID WP_002208622.1
Coordinates 3375787..3375990 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag EL213_RS15365 Protein ID WP_002218472.1
Coordinates 3375370..3375738 (+) Length 123 a.a.

Genomic Context

EL213_RS15350EL213_RS15355EL213_RS15360EL213_RS15365EL213_RS15370EL213_RS15380EL213_RS15390EL213_RS15385EL213_RS15395EL213_RS15400
Location: 3373575..3373835 (261 bp)
Type: Others
Protein ID: WP_002208617.1
Location: 3373851..3373994 (144 bp)
Type: Others
Protein ID: WP_002208618.1
Location: 3374858..3375211 (354 bp)
Type: Others
Protein ID: WP_002208619.1
Location: 3375370..3375738 (369 bp)
Type: Antitoxin
Protein ID: WP_002218472.1
Location: 3375787..3375990 (204 bp)
Type: Toxin
Protein ID: WP_002208622.1
Location: 3376860..3377249 (390 bp)
Type: Others
Protein ID: WP_024063215.1
Location: 3378163..3379023 (861 bp)
Type: Others
Protein ID: WP_002208625.1
Location: 3377385..3377906 (522 bp)
Type: Others
Protein ID: WP_011191872.1
Location: 3379284..3380573 (1290 bp)
Type: Others
Protein ID: WP_002228344.1
Location: 3380613..3380951 (339 bp)
Type: Others
Protein ID: WP_002208627.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EL213_RS153503373575..3373835+261WP_002208617.1type B 50S ribosomal protein L31-
EL213_RS153553373851..3373994+144WP_002208618.1type B 50S ribosomal protein L36-
EL213_RS153603374858..3375211+354WP_002208619.1hypothetical protein-
EL213_RS153653375370..3375738+369WP_002218472.1Hha toxicity modulator TomBAntitoxin
EL213_RS153703375787..3375990+204WP_002208622.1expression modulating protein YmoAToxin
EL213_RS153803376860..3377249+390WP_024063215.1MGMT family protein-
EL213_RS153853377385..3377906-522WP_011191872.1YbaY family lipoprotein-
EL213_RS153903378163..3379023+861WP_002208625.1acyl-CoA thioesterase II-
EL213_RS153953379284..3380573-1290WP_002228344.1ammonium transporter AmtB-
EL213_RS154003380613..3380951-339WP_002208627.1P-II family nitrogen regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T287828 WP_002208622.1 NZ_LR134373:3375787-3375990 [Yersinia pseudotuberculosis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT287828 WP_002218472.1 NZ_LR134373:3375370-3375738 [Yersinia pseudotuberculosis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB2K5S

Antitoxin

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Source
ID
Structure
AlphaFold DBQ66DR4

References