Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3375370..3375990 Replicon chromosome
Accession NZ_LR134373
Organism Yersinia pseudotuberculosis strain NCTC10275

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag EL213_RS15370 Protein ID WP_002208622.1
Coordinates 3375787..3375990 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag EL213_RS15365 Protein ID WP_002218472.1
Coordinates 3375370..3375738 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL213_RS15350 3373575..3373835 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
EL213_RS15355 3373851..3373994 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
EL213_RS15360 3374858..3375211 + 354 WP_002208619.1 hypothetical protein -
EL213_RS15365 3375370..3375738 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
EL213_RS15370 3375787..3375990 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
EL213_RS15380 3376860..3377249 + 390 WP_024063215.1 MGMT family protein -
EL213_RS15385 3377385..3377906 - 522 WP_011191872.1 YbaY family lipoprotein -
EL213_RS15390 3378163..3379023 + 861 WP_002208625.1 acyl-CoA thioesterase II -
EL213_RS15395 3379284..3380573 - 1290 WP_002228344.1 ammonium transporter AmtB -
EL213_RS15400 3380613..3380951 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T287828 WP_002208622.1 NZ_LR134373:3375787-3375990 [Yersinia pseudotuberculosis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT287828 WP_002218472.1 NZ_LR134373:3375370-3375738 [Yersinia pseudotuberculosis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References