Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 1987563..1988563 Replicon chromosome
Accession NZ_LR134373
Organism Yersinia pseudotuberculosis strain NCTC10275

Toxin (Protein)


Gene name - Uniprot ID Q66A68
Locus tag EL213_RS08895 Protein ID WP_011192520.1
Coordinates 1987563..1988021 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag EL213_RS08900 Protein ID WP_002210982.1
Coordinates 1988117..1988563 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL213_RS08865 1983377..1984042 + 666 WP_002210975.1 phage shock protein PspA -
EL213_RS08870 1984204..1984431 + 228 WP_002210976.1 envelope stress response membrane protein PspB -
EL213_RS08875 1984431..1984790 + 360 WP_024062896.1 envelope stress response membrane protein PspC -
EL213_RS08880 1984875..1985117 + 243 WP_002216375.1 phage shock protein PspD -
EL213_RS08885 1985098..1986495 + 1398 WP_012105043.1 YcjX family protein -
EL213_RS08890 1986492..1987553 + 1062 WP_012413752.1 YcjF family protein -
EL213_RS08895 1987563..1988021 - 459 WP_011192520.1 RES family NAD+ phosphorylase Toxin
EL213_RS08900 1988117..1988563 - 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
EL213_RS08905 1988900..1990477 + 1578 WP_024062895.1 transcriptional regulator TyrR -
EL213_RS08910 1990624..1991127 - 504 WP_002210984.1 thiol peroxidase -
EL213_RS08915 1991290..1992264 + 975 WP_024062894.1 L-Ala-D/L-Glu epimerase -
EL213_RS08920 1992289..1992996 - 708 WP_032466942.1 murein tripeptide amidase MpaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17008.41 Da        Isoelectric Point: 4.8732

>T287823 WP_011192520.1 NZ_LR134373:c1988021-1987563 [Yersinia pseudotuberculosis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT287823 WP_002210982.1 NZ_LR134373:c1988563-1988117 [Yersinia pseudotuberculosis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q66A68

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References