Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 1987563..1988563 Replicon chromosome
Accession NZ_LR134373
Organism Yersinia pseudotuberculosis strain NCTC10275

Toxin (Protein)


Gene name - Uniprot ID Q66A68
Locus tag EL213_RS08895 Protein ID WP_011192520.1
Coordinates 1987563..1988021 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag EL213_RS08900 Protein ID WP_002210982.1
Coordinates 1988117..1988563 (-) Length 149 a.a.

Genomic Context

EL213_RS08865EL213_RS08870EL213_RS08875EL213_RS08880EL213_RS08885EL213_RS08890EL213_RS08905EL213_RS08915EL213_RS08895EL213_RS08900EL213_RS08910EL213_RS08920
Location: 1983377..1984042 (666 bp)
Type: Others
Protein ID: WP_002210975.1
Location: 1984204..1984431 (228 bp)
Type: Others
Protein ID: WP_002210976.1
Location: 1984431..1984790 (360 bp)
Type: Others
Protein ID: WP_024062896.1
Location: 1984875..1985117 (243 bp)
Type: Others
Protein ID: WP_002216375.1
Location: 1985098..1986495 (1398 bp)
Type: Others
Protein ID: WP_012105043.1
Location: 1986492..1987553 (1062 bp)
Type: Others
Protein ID: WP_012413752.1
Location: 1988900..1990477 (1578 bp)
Type: Others
Protein ID: WP_024062895.1
Location: 1991290..1992264 (975 bp)
Type: Others
Protein ID: WP_024062894.1
Location: 1987563..1988021 (459 bp)
Type: Toxin
Protein ID: WP_011192520.1
Location: 1988117..1988563 (447 bp)
Type: Antitoxin
Protein ID: WP_002210982.1
Location: 1990624..1991127 (504 bp)
Type: Others
Protein ID: WP_002210984.1
Location: 1992289..1992996 (708 bp)
Type: Others
Protein ID: WP_032466942.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EL213_RS088651983377..1984042+666WP_002210975.1phage shock protein PspA-
EL213_RS088701984204..1984431+228WP_002210976.1envelope stress response membrane protein PspB-
EL213_RS088751984431..1984790+360WP_024062896.1envelope stress response membrane protein PspC-
EL213_RS088801984875..1985117+243WP_002216375.1phage shock protein PspD-
EL213_RS088851985098..1986495+1398WP_012105043.1YcjX family protein-
EL213_RS088901986492..1987553+1062WP_012413752.1YcjF family protein-
EL213_RS088951987563..1988021-459WP_011192520.1RES family NAD+ phosphorylaseToxin
EL213_RS089001988117..1988563-447WP_002210982.1DUF2384 domain-containing proteinAntitoxin
EL213_RS089051988900..1990477+1578WP_024062895.1transcriptional regulator TyrR-
EL213_RS089101990624..1991127-504WP_002210984.1thiol peroxidase-
EL213_RS089151991290..1992264+975WP_024062894.1L-Ala-D/L-Glu epimerase-
EL213_RS089201992289..1992996-708WP_032466942.1murein tripeptide amidase MpaA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17008.41 Da        Isoelectric Point: 4.8732

>T287823 WP_011192520.1 NZ_LR134373:c1988021-1987563 [Yersinia pseudotuberculosis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT287823 WP_002210982.1 NZ_LR134373:c1988563-1988117 [Yersinia pseudotuberculosis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ66A68

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E8XFL1

References