Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 243497..244131 Replicon chromosome
Accession NZ_LR134365
Organism Cardiobacterium hominis strain NCTC10426

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL199_RS01080 Protein ID WP_004141166.1
Coordinates 243497..243898 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C8N9V4
Locus tag EL199_RS01085 Protein ID WP_004141165.1
Coordinates 243898..244131 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL199_RS01055 239040..239936 - 897 WP_126315949.1 tetratricopeptide repeat protein -
EL199_RS01060 239983..240777 - 795 WP_004141170.1 ABC transporter permease -
EL199_RS01065 240774..241538 - 765 WP_004141169.1 ABC transporter ATP-binding protein -
EL199_RS01070 241538..242518 - 981 WP_004141168.1 ABC transporter substrate-binding protein -
EL199_RS01075 242666..243223 + 558 WP_004141167.1 RNA 2'-phosphotransferase -
EL199_RS01080 243497..243898 - 402 WP_004141166.1 tRNA(fMet)-specific endonuclease VapC Toxin
EL199_RS01085 243898..244131 - 234 WP_004141165.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EL199_RS01090 244463..246016 + 1554 WP_081447823.1 sodium/proline symporter PutP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15149.44 Da        Isoelectric Point: 7.8756

>T287817 WP_004141166.1 NZ_LR134365:c243898-243497 [Cardiobacterium hominis]
MLTYMLDTNTIIYTMKNRPAGMQERFNRLVSQLCISSITAAELCFGVEKSAWPERNRADLEDFFSRLEILPYGLKAAYHY
GNIRFQLQKAGKVIGGNDIHIAAHARSEGLVLISNNLAEFQRVEGLRLENWVV

Download         Length: 402 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9089.08 Da        Isoelectric Point: 4.4944

>AT287817 WP_004141165.1 NZ_LR134365:c244131-243898 [Cardiobacterium hominis]
MSEGTVFMNNRTQAVRLPADMRFDENVKKVEVRKQGNERIISPAGQSWDSFFAKPKEQWLSEDFSVEQEPPQEREDW

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB C8N9V4

References