Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 3168099..3168657 Replicon chromosome
Accession NZ_LR134363
Organism Actinomyces slackii strain NCTC11923

Toxin (Protein)


Gene name mazF Uniprot ID A0A3S4SRE2
Locus tag EL266_RS13095 Protein ID WP_026426458.1
Coordinates 3168334..3168657 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EL266_RS13090 Protein ID WP_026426459.1
Coordinates 3168099..3168347 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL266_RS13070 3164351..3165115 - 765 WP_026426462.1 NADH-quinone oxidoreductase subunit C -
EL266_RS13075 3165112..3165732 - 621 WP_026426461.1 NADH-quinone oxidoreductase subunit B -
EL266_RS13080 3165770..3166129 - 360 WP_026426460.1 NADH-quinone oxidoreductase subunit A -
EL266_RS13085 3166126..3167493 - 1368 WP_084500523.1 geranylgeranyl reductase family protein -
EL266_RS13090 3168099..3168347 + 249 WP_026426459.1 translation repressor RelB Antitoxin
EL266_RS13095 3168334..3168657 + 324 WP_026426458.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL266_RS13100 3169030..3169413 - 384 WP_126412402.1 hypothetical protein -
EL266_RS13105 3169811..3170353 - 543 WP_126412404.1 hypothetical protein -
EL266_RS13110 3170553..3171251 - 699 WP_126412406.1 hypothetical protein -
EL266_RS13115 3171281..3173443 - 2163 WP_126412408.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11921.90 Da        Isoelectric Point: 6.3094

>T287816 WP_026426458.1 NZ_LR134363:3168334-3168657 [Actinomyces slackii]
MLRGEVWTLRDKAYAAKARPVIVVQDETVASFDSIILCLLTTFDMKDAPTRVRIDPDENNGLMKTSYAMTDKIVTVDKKM
LGERVGTIETTQMNAISTQLARLLGIT

Download         Length: 324 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9165.19 Da        Isoelectric Point: 4.3440

>AT287816 WP_026426459.1 NZ_LR134363:3168099-3168347 [Actinomyces slackii]
MALKQATTRIEDDEYELFRATTRALGTTPADALRMFIYAFNEHRGFPYDVRTSKPTLEAFETEEDATRFATELALGVADA
AG

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S4SRE2

Antitoxin

Source ID Structure

References