Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1858319..1858901 Replicon chromosome
Accession NZ_LR134363
Organism Actinomyces slackii strain NCTC11923

Toxin (Protein)


Gene name vapC Uniprot ID A0A448KDA6
Locus tag EL266_RS07740 Protein ID WP_026427606.1
Coordinates 1858539..1858901 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A448KDA7
Locus tag EL266_RS07735 Protein ID WP_026427605.1
Coordinates 1858319..1858528 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL266_RS07720 1853467..1853658 - 192 WP_003785965.1 50S ribosomal protein L28 -
EL266_RS07725 1853960..1855840 + 1881 WP_034515331.1 DAK2 domain-containing protein -
EL266_RS07730 1856021..1858270 + 2250 WP_026427604.1 ATP-dependent DNA helicase RecG -
EL266_RS07735 1858319..1858528 + 210 WP_026427605.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
EL266_RS07740 1858539..1858901 + 363 WP_026427606.1 type II toxin-antitoxin system VapC family toxin Toxin
EL266_RS07745 1858946..1859524 - 579 WP_026427607.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
EL266_RS07750 1859644..1860141 + 498 WP_026427608.1 pantetheine-phosphate adenylyltransferase -
EL266_RS07755 1860176..1860745 + 570 WP_026427609.1 ATPase -
EL266_RS07760 1860854..1861411 + 558 WP_026427610.1 DUF177 domain-containing protein -
EL266_RS07765 1861411..1862229 + 819 WP_026427611.1 ribonuclease III -
EL266_RS07770 1862222..1863304 + 1083 WP_026427612.1 bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13535.55 Da        Isoelectric Point: 7.3613

>T287815 WP_026427606.1 NZ_LR134363:1858539-1858901 [Actinomyces slackii]
MILIDTNVWIDHLHVSDNRLVALLERDEAATHEAVLTELALGSIKNREKVLNSLGSLRRVPQISDCEVRWFTERRRLWGR
GLSAVDVHLLASVVAERGALLWTRDKRLAAAADELGVGYR

Download         Length: 363 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7576.57 Da        Isoelectric Point: 6.9794

>AT287815 WP_026427605.1 NZ_LR134363:1858319-1858528 [Actinomyces slackii]
MRTTITLDDDLVERASELTGITERAALVRQAVSTLIRVESSRRLIALGGSDPAAEAAPRHRGMRDRQDC

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A448KDA6

Antitoxin

Source ID Structure
AlphaFold DB A0A448KDA7

References