Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 251379..252993 Replicon chromosome
Accession NZ_LR134361
Organism Achromobacter insolitus strain NCTC13520

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EL339_RS01195 Protein ID WP_076817034.1
Coordinates 251641..252993 (+) Length 451 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A6S7FIA7
Locus tag EL339_RS01190 Protein ID WP_042795666.1
Coordinates 251379..251636 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL339_RS01175 247029..248060 + 1032 WP_042797454.1 sugar ABC transporter -
EL339_RS01180 248053..249957 + 1905 WP_076817032.1 Vi polysaccharide transport protein VexE -
EL339_RS01185 249970..251190 + 1221 WP_042795667.1 polysaccharide lyase family 1 protein -
EL339_RS01190 251379..251636 + 258 WP_042795666.1 helix-turn-helix domain-containing protein Antitoxin
EL339_RS01195 251641..252993 + 1353 WP_076817034.1 type II toxin-antitoxin system HipA family toxin Toxin
EL339_RS01200 253024..253791 - 768 WP_042795664.1 helix-turn-helix transcriptional regulator -
EL339_RS01205 253884..255005 + 1122 WP_076818077.1 MFS transporter -
EL339_RS01210 255002..255673 - 672 WP_063639549.1 Crp/Fnr family transcriptional regulator -
EL339_RS01215 255900..257114 + 1215 WP_088607648.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(159-377)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 451 a.a.        Molecular weight: 49403.60 Da        Isoelectric Point: 7.7800

>T287814 WP_076817034.1 NZ_LR134361:251641-252993 [Achromobacter insolitus]
MGRRSHTQVLGLWMNGAYVGEWSNRPHAGEVLQYDKDWVASAPGRPLSLSLPFTPGNGPHRGDVVRAYFENLLPDSKEIR
ERVARRFRAGSTDAFALLAEIGRDCAGALQILPAGTAPADVASVQASPLNDAQVAQLLRSVLAPAPLGGLAIAEDDFRIS
IAGAQEKTALLRIDGQWCLPQGATPTTHILKLPLGLVGNMKFDLSESVENEWLCSEILAAYGMPVARAEVLSFEDMKVLA
VERFDRRWWDGEDGKRSLVRLPQEDMCQATGTPPHLKYEADGGPGIDRIMGLLETSRRSEHDRRTFFQAQVLFWMLCATD
GHAKNFSLFLRPGGAYELTPLYDVLSAYPILGEGPGKLSPVRAKMAMAVRSKNPHWRMRDIQRRHWLTVGARHGVVTPDG
KGVQFVVDDLIARTPEVVRAVRARLPQGFPRVLADSILDGLQAAADRLAA

Download         Length: 1353 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9220.58 Da        Isoelectric Point: 8.9814

>AT287814 WP_042795666.1 NZ_LR134361:251379-251636 [Achromobacter insolitus]
MDFTVRTATQLPALLQGFRKEAGLTQAATALRLGVTQQTLSALERNADKVSADRLLQLLSILGVEMVLRRQGAQPGPETT
SEPSW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6S7FIA7

References