Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1004259..1004773 Replicon chromosome
Accession NZ_LR134360
Organism Staphylococcus condimenti strain NCTC13827

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EL167_RS04495 Protein ID WP_082107871.1
Coordinates 1004423..1004773 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID B9DMI8
Locus tag EL167_RS04490 Protein ID WP_015900820.1
Coordinates 1004259..1004426 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL167_RS04465 1000180..1000650 + 471 WP_047132374.1 PH domain-containing protein -
EL167_RS04470 1000643..1002115 + 1473 WP_047132375.1 PH domain-containing protein -
EL167_RS04475 1002120..1002605 + 486 WP_063164645.1 PH domain-containing protein -
EL167_RS04480 1002607..1002960 + 354 WP_047132377.1 holo-ACP synthase -
EL167_RS04485 1003024..1004178 + 1155 WP_047132378.1 alanine racemase -
EL167_RS04490 1004259..1004426 + 168 WP_015900820.1 hypothetical protein Antitoxin
EL167_RS04495 1004423..1004773 + 351 WP_082107871.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL167_RS04500 1005041..1006357 - 1317 WP_063164607.1 ISL3 family transposase -
EL167_RS04505 1006602..1007603 + 1002 WP_047133046.1 PP2C family protein-serine/threonine phosphatase -
EL167_RS04510 1007680..1008006 + 327 WP_015900817.1 anti-sigma factor antagonist -
EL167_RS04515 1008008..1008487 + 480 WP_047133045.1 anti-sigma B factor RsbW -
EL167_RS04520 1008462..1009232 + 771 WP_047133044.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1005041..1006357 1316


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13093.22 Da        Isoelectric Point: 10.0708

>T287813 WP_082107871.1 NZ_LR134360:1004423-1004773 [Staphylococcus condimenti]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAMTGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TVDKKRLKEKLTYLSDEKMKEIDNAIQISLGLTHRN

Download         Length: 351 bp

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6211.75 Da        Isoelectric Point: 3.6836

>AT287813 WP_015900820.1 NZ_LR134360:1004259-1004426 [Staphylococcus condimenti]
MSTFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFSVECEACDCNESYLAFDKDE

Download         Length: 168 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A380F5Y4

References