287812

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 990912..991423 Replicon chromosome
Accession NZ_LR134360
Organism Staphylococcus condimenti strain NCTC13827

Toxin (Protein)


Gene name TsdT Uniprot ID A0A143PEZ9
Locus tag EL167_RS04430 Protein ID WP_047132367.1
Coordinates 991217..991423 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID B9DMH6
Locus tag EL167_RS04425 Protein ID WP_015900833.1
Coordinates 990912..991205 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL167_RS04400 986279..986917 + 639 WP_047132363.1 thiamine phosphate synthase -
EL167_RS04405 987006..987881 + 876 WP_047132364.1 membrane protein insertase YidC -
EL167_RS04410 987992..988504 + 513 WP_047132365.1 GNAT family N-acetyltransferase -
EL167_RS04415 988595..989242 - 648 WP_047132366.1 HD domain-containing protein -
EL167_RS04420 989267..990747 - 1481 Protein_880 cardiolipin synthase -
EL167_RS04425 990912..991205 + 294 WP_015900833.1 copper-sensing transcriptional repressor CsoR Antitoxin
EL167_RS04430 991217..991423 + 207 WP_047132367.1 cation transporter Toxin
EL167_RS04435 991438..991647 + 210 WP_047132368.1 copper ion binding protein -
EL167_RS04440 991744..993945 + 2202 WP_047132369.1 heavy metal translocating P-type ATPase -
EL167_RS12855 994021..994161 + 141 WP_165380001.1 hypothetical protein -
EL167_RS04445 994241..995452 - 1212 WP_047132370.1 rod shape-determining protein RodA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(27-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7815.73 Da        Isoelectric Point: 4.1353

>T287812 WP_047132367.1 NZ_LR134360:991217-991423 [Staphylococcus condimenti]
MQNSVIKIDGMETEEEQHKLHQHLIEMTGVTAVQVDLDSNEIKISYETPVNLNNLEKEIYDAGYQILN

Download         Length: 207 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11132.76 Da        Isoelectric Point: 6.4862

>AT287812 WP_015900833.1 NZ_LR134360:990912-991205 [Staphylococcus condimenti]
MTENDKAHHSEQIKSNLKARLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAVRLLDHHMKGCIMHKVEDGHA
EEAMEELLVTVQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A143PEZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A380F6K8

References