28781

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3769572..3770101 Replicon chromosome
Accession NC_020089
Organism Mycobacterium tuberculosis 7199-99

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag MT7199_RS17645 Protein ID WP_003417760.1
Coordinates 3769844..3770101 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag MT7199_RS17640 Protein ID WP_003417757.1
Coordinates 3769572..3769847 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT7199_RS22805 3766370..3767807 - 1438 Protein_3457 FAD-binding oxidoreductase -
MT7199_RS17625 3767910..3768299 + 390 WP_003417745.1 DUF732 domain-containing protein -
MT7199_RS17630 3768313..3768606 - 294 WP_003417749.1 DUF3017 domain-containing protein -
MT7199_RS17635 3768603..3769448 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
MT7199_RS17640 3769572..3769847 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
MT7199_RS17645 3769844..3770101 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
MT7199_RS17650 3770143..3771333 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
MT7199_RS17655 3771450..3771818 + 369 WP_003417765.1 FHA domain-containing protein -
MT7199_RS17660 3771815..3772366 - 552 WP_015345178.1 pentapeptide repeat protein MfpA -
MT7199_RS17665 3772373..3772954 - 582 WP_003417769.1 ATP/GTP-binding protein -
MT7199_RS17670 3772935..3773303 - 369 WP_003417772.1 DUF742 domain-containing protein -
MT7199_RS17675 3773281..3773673 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T28781 WP_003417760.1 NC_020089:3769844-3770101 [Mycobacterium tuberculosis 7199-99]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T28781 NC_020089:3769844-3770101 [Mycobacterium tuberculosis 7199-99]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT28781 WP_003417757.1 NC_020089:3769572-3769847 [Mycobacterium tuberculosis 7199-99]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT28781 NC_020089:3769572-3769847 [Mycobacterium tuberculosis 7199-99]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
AlphaFold DB G0TI94

References