Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 5317131..5317819 Replicon chromosome
Accession NZ_LR134355
Organism Mycolicibacterium chitae strain NCTC10485

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL338_RS25315 Protein ID WP_126336367.1
Coordinates 5317382..5317819 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EL338_RS25310 Protein ID WP_126336365.1
Coordinates 5317131..5317385 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL338_RS25285 5312351..5313457 - 1107 WP_126336357.1 NAD(P)/FAD-dependent oxidoreductase -
EL338_RS25290 5313671..5314420 - 750 WP_126336359.1 SDR family oxidoreductase -
EL338_RS25295 5314538..5315095 + 558 WP_126336361.1 TetR/AcrR family transcriptional regulator -
EL338_RS25300 5315133..5316521 - 1389 WP_126336363.1 sodium:alanine symporter family protein -
EL338_RS25305 5316663..5317007 - 345 WP_126337135.1 hypothetical protein -
EL338_RS25310 5317131..5317385 + 255 WP_126336365.1 antitoxin Antitoxin
EL338_RS25315 5317382..5317819 + 438 WP_126336367.1 type II toxin-antitoxin system VapC family toxin Toxin
EL338_RS25320 5317828..5318313 - 486 WP_126336369.1 SRPBCC domain-containing protein -
EL338_RS25325 5318318..5318659 - 342 WP_179967135.1 metalloregulator ArsR/SmtB family transcription factor -
EL338_RS25330 5318767..5319006 + 240 WP_126336371.1 hypothetical protein -
EL338_RS25335 5319011..5320116 - 1106 Protein_5008 glutamate--cysteine ligase -
EL338_RS25340 5320214..5320720 - 507 WP_126337139.1 peptidoglycan recognition protein family protein -
EL338_RS25345 5321211..5322797 + 1587 WP_126336373.1 serine/threonine protein kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(3-140)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15442.55 Da        Isoelectric Point: 6.7582

>T287809 WP_126336367.1 NZ_LR134355:5317382-5317819 [Mycolicibacterium chitae]
VKIVDANVLLYAVNSASPQHEASRRWLDGALSGSDTVGLAWVPLLAFVRLSTKTGLFPSPLPPADAMRQVVEWATAPGAT
TIAPTARHGDILHTLLAQLGTGGNIVSDAHLAALAIEHRASIVSYDNDFSRFDGVRWHTPDALVK

Download         Length: 438 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9398.69 Da        Isoelectric Point: 8.9931

>AT287809 WP_126336365.1 NZ_LR134355:5317131-5317385 [Mycolicibacterium chitae]
MRTTVTLDDDTLALVQRRMRERGVSFKTALNDAIRDGALGQPRPVHFATRTADLGVPTVNLDRALQLAAELEDEELLRKQ
RRGA

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References